Investigating immune cells and proteins to understand sarcoidosis severity
Official title: Using high T-bet-expressing cells and Serum Chemokines as Indicators of Disease Severity in Sarcoidosis
Funded at University of California, San Francisco · NIH-10897084 · Data updated 2026-11-12
This study is looking at how certain immune cells and proteins in your blood relate to the severity of sarcoidosis and how well your lungs are working, so we can better understand the disease and improve treatment for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $179,958 |
| NIH project number | 5K23HL156000-04 |
| Project ID | NIH-10897084 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sarcoidosis, particularly those experiencing varying degrees of lung involvement.
✕Less likely to help
Patients with other respiratory conditions or those without a diagnosis of sarcoidosis may not benefit from this research.
What this research studies
This research focuses on sarcoidosis, a disease that can affect multiple organs, particularly the lungs. It aims to identify specific immune cells and proteins that correlate with the severity of the disease and lung function in patients. By analyzing blood markers linked to inflammation, the study seeks to provide better insights into the disease's progression and treatment responses. Patients will be monitored over time to gather data on these immune markers and their relationship to clinical outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for assessing disease severity in sarcoidosis, potentially guiding more effective treatment strategies.
How similar studies have gone: Previous research has shown promise in using immune markers to assess disease severity in other conditions, suggesting potential for success in this novel approach for sarcoidosis.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Arger, Nicholas Kostandinos — University of California, San Francisco
- Study coordinator: Arger, Nicholas Kostandinos
Related research
Other NIH-funded projects on the same topics.
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Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
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Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism
Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.
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Understanding how inflammation and scarring develop in pulmonary sarcoidosis
A doctor-scientist is studying why some people with sarcoidosis develop dangerous lung scarring and how to prevent it.
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Peptide-based Diagnostic Test for Sarcoidosis
A new test using peptide-based ELISA is being developed to diagnose sarcoidosis, potentially reducing the need for invasive lung biopsies.
-
Molecular markers of progressive pulmonary sarcoidosis
This grant looks at proteins and genes in people with sarcoidosis to find early signs that the disease will worsen from the lungs.
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Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis
A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.