Cell competition in lung fibrosis and ARDS
Official title: Cell competition in pulmonary fibrosis and ARDS
Funded at Mayo Clinic Rochester · NIH-11392294 · Data updated 2026-11-12
A Mayo Clinic team is studying how lung cells compete and repair after injury in people with severe lung diseases like IPF, ARDS, and after viral infections, to find ways to improve recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 20, 2022 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $934,920 |
| NIH project number | 5R35HL161169-05 |
| Project ID | NIH-11392294 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with idiopathic pulmonary fibrosis or acute respiratory distress syndrome, especially those with a history of viral exposure or COVID-19-related complications, who could contribute tissue samples or participate in observational aspects.
✕Less likely to help
Patients with non-fibrotic, stable lung disease or without ARDS/ILD symptoms may see little direct benefit.
What this research studies
This project looks at how different lung cell types interact and compete during injury and repair in conditions such as idiopathic pulmonary fibrosis and acute respiratory distress syndrome, including complications from viral infections like COVID-19. Researchers will examine cellular behavior and repair mechanisms in lung tissue and model systems to understand why rapid progression and fibrotic remodeling occur. The goal is to identify cellular pathways that could be targeted to prevent scarring and improve lung function after injury. The work is led by Mayo Clinic Rochester and aims to translate findings toward better treatments for patients with severe lung disease.
Why it matters
Potential benefit: If successful, the research could reveal targets to slow or prevent lung scarring and improve outcomes for patients with IPF and ARDS, including those recovering from viral infections.
How similar studies have gone: Prior studies in lung injury and fibrosis have shown that epithelial cell behavior and repair pathways influence disease progression, supporting the potential for meaningful insights here.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: De Langhe, Stijn Piet Johan — Mayo Clinic Rochester
- Study coordinator: De Langhe, Stijn Piet Johan
Related research
Other NIH-funded projects on the same topics.
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How lung cells compete in pulmonary fibrosis and ARDS
This project looks at how some lung cells outcompete others to help explain scarring in people with pulmonary fibrosis and sudden severe lung injury (ARDS).
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Investigating cell competition in lung diseases like pulmonary fibrosis and ARDS
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Molecular clues to progressive lung scarring
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Alveolar Cell Dysfunction in Pulmonary Fibrosis: Using SFTPC Mutations to Find New Targets
This grant explores how rare SFTPC mutations in alveolar cells may drive IPF and seeks new molecular targets to improve treatment.
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Iron and scar-forming cells in the lungs (IPF)
Researchers are exploring how iron in the lungs may drive the scarring seen in idiopathic pulmonary fibrosis and whether this could lead to new therapies.
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Repurposing Pyrvinium as an Inhaled Therapy for Idiopathic Pulmonary Fibrosis
A patient-friendly look at a project trying to use an existing drug, pyrvinium, as an inhaled treatment option for idiopathic pulmonary fibrosis (IPF).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.