Pre-Clinical Models of ARDS/VILI in Rats and Pigs
Official title: Pre-Clinical Large and Small Animal Models of ARDS/VILI
Funded at University of Florida · NIH-11417279 · Data updated 2026-11-12
A large animal and rat project to understand how lung injury develops in ARDS and ventilation-related damage, with work aimed at developing better therapies and translating findings to patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 20, 2016 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $267,737 |
| NIH project number | 5P01HL126609-10 |
| Project ID | NIH-11417279 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with acute respiratory distress syndrome or severe lung injury who may benefit from future ARDS therapies derived from this research.
✕Less likely to help
Healthy individuals or patients not affected by ARDS/VILI are unlikely to benefit directly.
What this research studies
This grant funds a core that creates and uses rigorously defined rat and pig models of ARDS combined with ventilation-induced lung injury. It focuses on how the endothelial cytoskeleton affects lung barrier function and tests potential therapeutic strategies. The core provides training, equipment, and data tools to four projects, and manages animal care and experimental resources. The aim is to bridge basic discoveries in the lab to clinical interventions that could help patients with ARDS.
Why it matters
Potential benefit: If successful, the work could lead to new treatment approaches for ARDS and VILI that may improve oxygenation and survival in patients.
How similar studies have gone: Previous animal model work has advanced understanding of ARDS, but this program seeks deeper mechanistic insights with translational potential.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Sammani, Saad — University of Florida
- Study coordinator: Sammani, Saad
Related research
Other NIH-funded projects on the same topics.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
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-
Lipid-gene Profiles in Septic ARDS
A Mayo Clinic team is studying how dysfunctional HDL in sepsis relates to different ARDS patient outcomes, aiming to find features that could guide better treatment.
-
Improving blood vessel repair after pediatric ARDS
Aims to better repair the lungs of children who have ARDS by delivering targeted therapy to lung blood vessels using tiny nanoparticles.
-
NOX4 links to ARDS risk and progression
Aims to understand how NOX4-driven cell damage may make some adults with ARDS worse off and how this could lead to earlier, targeted care.
-
Leading causes of death in alcoholic ARDS patients using clinical data
This project uses big clinical data and AI to find the main factors that cause death in adults with ARDS who have alcohol use issues, aiming to improve understanding and care.
-
Targeting aging-related blood vessel injury to prevent ARDS in older lungs
Aims to find ways to protect lung blood vessels in older adults to prevent dangerous lung swelling (ARDS).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.