TRMT1 and tRNA methylation in acute lung injury and ARDS
Official title: Examining the role of TRMT1 and tRNA methylation in acute lung injury and ARDS
Funded at Ohio State University · NIH-11365169 · Data updated 2026-11-12
Aims to understand how a RNA-modifying enzyme called TRMT1 affects lung injury and ARDS to help develop new treatments for patients in ICU.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $533,111 |
| NIH project number | 5R01HL169586-04 |
| Project ID | NIH-11365169 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with acute lung injury or ARDS who are hospitalized and may have infection-related components.
✕Less likely to help
Patients without ARDS or acute lung injury, or those not involved in studies using human samples or related data, may not benefit directly.
What this research studies
This grant studies how changes in tRNA methylation driven by TRMT1 influence the body's response to lung injury and critical illness. Researchers will explore TRMT1’s role in immune cell function, inflammation, and lung tissue damage during ARDS and related conditions. The work combines laboratory experiments with analyses of human samples to uncover mechanisms that could be targeted by future therapies. If successful, the findings could guide development of novel treatments to reduce mortality and improve recovery for people with severe respiratory failure.
Why it matters
Potential benefit: It could lead to new therapies that lessen lung damage and improve survival for ARDS patients.
How similar studies have gone: Previous work suggests tRNA biology and methylation influence immune responses, but applying this to ARDS is still emerging and promising.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Londino, James David — Ohio State University
- Study coordinator: Londino, James David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.