Understanding how lipid and gene profiles affect septic ARDS
Official title: Investigating Lipid-gene Molecular Profiles of Septic ARDS
Funded at University of Florida · NIH-11229094 · Data updated 2026-11-12
This study is looking at how certain fats and genes in the body affect patients with septic acute respiratory distress syndrome (ARDS) to understand why some people do worse than others, with the hope of finding better, personalized treatments for them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | June 10, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $424,223 |
| NIH project number | 1R21AI188477-01A1 |
| Project ID | NIH-11229094 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with septic ARDS, particularly those exhibiting the HYPO phenotype.
✕Less likely to help
Patients with ARDS not related to sepsis or those who do not fit the identified phenotypes may not benefit from this research.
What this research studies
This research investigates the relationship between lipid and gene profiles in patients suffering from septic acute respiratory distress syndrome (ARDS). By analyzing the differences in high-density lipoprotein (HDL) functionality and identifying distinct sepsis phenotypes, the study aims to uncover why some patients experience higher mortality rates than others. The research employs a panel of fifteen measurements, including lipoproteins and inflammatory markers, to characterize these patients and their responses to sepsis. This approach could lead to more personalized treatment strategies for those affected by septic ARDS.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve survival rates for patients with septic ARDS.
How similar studies have gone: While the specific approach of analyzing lipid-gene profiles in septic ARDS is novel, similar studies have shown promise in understanding sepsis and ARDS through phenotyping.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Guirgis, Faheem W — University of Florida
- Study coordinator: Guirgis, Faheem W
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.