Role of endothelial NAMPT in ARDS: a target to reduce lung inflammation
Official title: Role of Endothelial eNAMPT/NAMPT secretion and TLR4 signaling in the ARDS Vascular Endotype
Funded at University of Florida · NIH-11417289 · Data updated 2026-11-12
Researchers are studying how a molecule called NAMPT released by blood vessel cells contributes to lung inflammation in ARDS and how blocking its signals might help patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 20, 2016 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $267,735 |
| NIH project number | 5P01HL126609-10 |
| Project ID | NIH-11417289 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with ARDS, including COVID-19 related cases, or those at risk of ventilator-induced lung injury.
✕Less likely to help
As a basic-to-preclinical study, direct patient benefit may not occur immediately but could inform future therapies.
What this research studies
This project focuses on how NAMPT in the blood vessels promotes lung inflammation and makes the lungs more permeable during ARDS, including cases from COVID-19 and ventilator-associated injury. It builds on lab and animal studies to understand how NAMPT acts as a danger signal through TLR4 pathways. The team will explore whether stopping NAMPT’s harmful signals can lessen lung injury and improve outcomes. Results could point toward new therapies that reduce inflammation and vascular leakage in ARDS patients.
Why it matters
Potential benefit: If successful, the work could lead to new treatments that lessen lung damage and improve survival for people with ARDS.
How similar studies have gone: Prior research has linked NAMPT/TLR4 signaling to lung inflammation, with animal studies showing that targeting this pathway can reduce injury.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Garcia, Joe G. N. — University of Florida
- Study coordinator: Garcia, Joe G. N.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.