Understanding why some people with sepsis develop ARDS after ozone exposure
Official title: Mechanisms underlying susceptibility to ozone-induced ARDS
Funded at Rutgers Biomedical and Health Sciences · NIH-11274655 · Data updated 2026-11-12
A study to learn why certain patients with sepsis develop acute lung injury and ARDS after exposure to air pollutants like ozone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | June 1, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $554,766 |
| NIH project number | 1R01HL183635-01 |
| Project ID | NIH-11274655 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with sepsis or at risk of ARDS, particularly those with genetic variations in SP-D and related inflammatory pathways.
✕Less likely to help
People without sepsis or those not exposed to ozone-related risk factors may not benefit from these findings.
What this research studies
This project looks at how ozone exposure might worsen lung injury in sepsis and why only some people are affected. Researchers will study immune cells in the lungs, especially alveolar macrophages and neutrophils, and how they clear inflammation. They will also examine a lung protein called SP-D and how genetic differences could influence inflammation and risk of ARDS. The goal is to identify biological factors that raise ARDS risk so future therapies can be targeted to high-risk patients.
Why it matters
Potential benefit: If successful, the findings could lead to better risk prediction and new interventions to prevent ARDS in vulnerable patients after sepsis and air pollution exposure.
How similar studies have gone: There is prior evidence linking ozone exposure to worse lung inflammation and macrophage dysfunction, but detailed mechanisms and genetic influences remain under investigation.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Radbel, Jared M. — Rutgers Biomedical and Health Sciences
- Study coordinator: Radbel, Jared M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.