Role of oxygen-sensing enzymes in protecting lungs during ARDS
Official title: Functional Role of HIF-PHDs in ARDS
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11406237 · Data updated 2026-11-12
A study in people is not directly involved; the grant tests how specific enzymes in the lungs control inflammation during ARDS using animal models and lab studies to better understand potential treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $664,541 |
| NIH project number | 5R01HL169519-04 |
| Project ID | NIH-11406237 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not currently enrolling patients; preclinical research using animal and cellular models.
✕Less likely to help
Direct patient benefit is not anticipated until later translational steps.
What this research studies
This project looks at how the body’s oxygen-sensing system in lung cells (HIF-PHDs) controls inflammation during ARDS. Researchers will study which PHD enzymes regulate HIF1A and how altering Phd1 affects lung injury in models that mimic ARDS. The goal is to identify mechanisms that could be targeted to reduce lung damage in patients with severe respiratory failure, including cases linked to infections like COVID-19. The work combines genetic and pharmacologic approaches in preclinical systems to pinpoint potential therapeutic strategies before testing in people.
Why it matters
Potential benefit: If successful, the findings could lead to new treatments that lessen lung injury and improve outcomes for people with ARDS.
How similar studies have gone: Previous work in the same line suggests targeting HIF pathways can modulate lung inflammation, with promising preclinical results.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Eltzschig, Holger K. — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Eltzschig, Holger K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.