Lipid-gene Profiles in Septic ARDS
Official title: Investigating Lipid-gene Molecular Profiles of Septic ARDS
Funded at Mayo Clinic Jacksonville · NIH-11575353 · Data updated 2026-11-12
A Mayo Clinic team is studying how dysfunctional HDL in sepsis relates to different ARDS patient outcomes, aiming to find features that could guide better treatment.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | June 10, 2025 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $221,191 |
| NIH project number | 7R21AI188477-02 |
| Project ID | NIH-11575353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with septic ARDS, particularly those fitting the HYPO or NORMO phenotypes identified by the research team.
✕Less likely to help
Patients without septic ARDS or who do not fit the identified phenotypes may not benefit from these findings.
What this research studies
This project looks at how HDL particles change during sepsis and how these changes relate to septic ARDS patients’ outcomes. Researchers have created a panel of fifteen measurements, identified two sepsis phenotypes (HYPO and NORMO), and observed worse outcomes and specific lipid signatures in HYPO septic ARDS patients. They will test whether these lipid and gene patterns can explain patient differences and potentially point to new therapeutic targets. The study is focused on human patients with septic ARDS and uses blood samples and clinical data to link biological markers with mortality and organ failure.
Why it matters
Potential benefit: If successful, the work could lead to more precise patient stratification and inform future therapies for septic ARDS.
How similar studies have gone: Early data show distinct mortality and biomarker patterns between HYPO and NORMO septic ARDS, supporting the potential for meaningful insights.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Guirgis, Faheem W — Mayo Clinic Jacksonville
- Study coordinator: Guirgis, Faheem W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.