TwitchView-guided Atracurium Dose Adjustment in ICU Patients
Official title: Target Dosage of Continuous Atracurium Infusion at a Moderate Level of Paralysis in Intensive Care Unit Patients Monitored by an Electromyography-Based Quantitative Neuromuscular Monitor
Run by Fu Jen Catholic University Hospital · NCT07807046 · Data updated 2026-11-12
This trial tests whether using a TwitchView EMG monitor to guide atracurium dosing in ICU patients reduces the total amount of the drug given without compromising care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Fu Jen Catholic University Hospital Academic / other |
| Locations | 1 site (New Taipei City) |
| Status | Recruiting |
| Started | August 19, 2026 |
| Main results expected | July 31, 2028 |
| Study ends | July 31, 2028 |
| Registry record updated | September 8, 2026 |
| Trial ID | NCT07807046 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal participants are adults (≥20 years) in the ICU requiring continuous atracurium infusion for ≥48 hours due to ARDS, post-cardiac arrest with TTM, or VV/VA ECMO support.
✕Probably not a fit
Patients who do not fit the inclusion criteria or have contraindications to atracurium may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults in the ICU who need continuous atracurium for more than 48 hours are randomized to dosing guided by a TwitchView EMG monitor or by standard bedside clinical assessment. The study compares 72-hour drug exposure and related complications between the two approaches, aiming to maintain a moderate level of paralysis. The intervention uses quantitative train-of-four measurements from a wrist/hand sensor to titrate the infusion. Background concerns include balancing effective paralysis with risks like pneumonia, thrombosis, and ICU-acquired weakness. The trial is conducted at Fu Jen Catholic University Hospital and is led by that institution.
Why it matters
Potential benefit: If successful, patients may receive less NMBA exposure with similar clinical effectiveness, potentially reducing related complications.
How similar studies have gone: Previous ICU studies using TOF-guided titration have shown mixed results; this trial tests a more precise EMG-based method.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult ICU patients (≥ 20 years of age) requiring continuous atracurium infusion for more than 48 hours due to any of the following conditions: * Moderate-to-severe ARDS (PaO₂/FiO₂ ratio ≤ 150) * Post-cardiac arrest care with device-controlled TTM (intravascular or surface cooling system) * Veno-venous (VV) or veno-arterial (VA) ECMO support Exclusion Criteria: * Patients aged under 20 years * Pregnant patients * Patients with known allergy to atracurium * Patients with a do-not-intervention order due to terminal disease * Patients with severe asthma, owing to the potential for atracurium-induced histamine release * Patients or their families who refuse to participate in the trial
Where it's running
-
Fu-Jen Catholic University Hospital
New Taipei City, Taiwan Recruiting
Study contacts
- Study coordinator: Herman Chih-Heng Chang, M.D., M.M.S.
- Email: herman90021@gmail.com
- Phone: +886-29056234
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.