Using a decision support tool to improve ventilation in children with ARDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to implement a Clinical Decision Support (CDS) tool to standardize ventilator management for infants and children suffering from Pediatric Acute Respiratory Distress Syndrome (PARDS). The CDS tool, developed at Children's Hospital Los Angeles, will be deployed across multiple Pediatric Intensive Care Units (PICUs) to enhance adherence to evidence-based practices in mechanical ventilation. The study will assess the feasibility, acceptability, and compliance with the CDS recommendations, targeting improvements in patient outcomes such as reduced time on mechanical ventilation and minimized ventilator-induced injuries. Data will be captured automatically to ensure timely and relevant information is provided to clinicians.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children \> 1 month of age and \>44 weeks gestation and ≤ 18 years of age AND
* Supported on mechanical ventilation with pulmonary parenchymal disease (i.e. Pediatric Acute Respiratory Distress Syndrome (PARDS)) with Oxygen Saturation Index (OSI) ≥ 5) or Oxygenation Index (OI) ≥ 4 AND
* Who are within 72 hours of initiation of invasive mechanical ventilation AND
* Who are anticipated to require \>72 hours mechanical ventilation.

Exclusion Criteria:

* Conditions on enrollment that preclude conventional methods of weaning (i.e., status asthmaticus, severe lower airway obstruction, bronchiolitis, critical airway, Extra Corporeal Life Support (ECLS), intubation for Upper Airway Obstruction, Do Not Resuscitate orders, severe chronic respiratory failure, spinal cord injury above lumbar region, cyanotic heart disease (unrepaired or palliated)) OR
* Conditions precluding the use of permissive hypercapnia or hypoxemia (i.e. intracranial hypertension, severe pulmonary hypertension)
* Primary Attending physician refuses to enroll the patient

Where it's running

• Ann & Robert H. Lurie Children's Hospital of Chicago
  Chicago, Illinois, United States Recruiting
• Riley Hospital for Children
  Indianapolis, Indiana, United States Recruiting
• Penn State University
  Hershey, Pennsylvania, United States Recruiting
• University of Wisconsin-Madison
  Madison, Wisconsin, United States Recruiting
• Children's Hospital of Wisconsin
  Milwaukee, Wisconsin, United States Recruiting
• CHU Sainte-Justine
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Christopher J Newth, MD — Children's Hospital Los Angeles
• Study coordinator: Christopher J Newth, MD
• Email: cnewth@chla.usc.edu
• Phone: 3233612557

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Measuring lung mechanics in patients on mechanical ventilation

  This study is testing how mechanical ventilation affects lung function in patients with breathing problems to help improve their care and reduce lung injury.

  Recruiting Göteborg University · Gothenburg, Västra Götaland County · NCT04484727

• Multicenter group study of sepsis and ARDS in China

  This study tests how sepsis and ARDS differ among adults across several Chinese hospitals and builds a biobank to understand why some patients do better or worse.

  Recruiting at 24 sites Shanghai Zhongshan Hospital · Xiamen, Fujian and 23 other locations · NCT07863908

• Blood viscosity in ARDS: a look at how thick the blood is

  This study tests whether blood viscosity is higher in adults with ARDS and whether viscosity relates to their breathing and blood flow issues.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07823296

• TwitchView-guided Atracurium Dose Adjustment in ICU Patients

  This trial tests whether using a TwitchView EMG monitor to guide atracurium dosing in ICU patients reduces the total amount of the drug given without compromising care.

  Recruiting Fu Jen Catholic University Hospital · New Taipei City · NCT07807046

• How different ventilator settings affect lung energy during gallbladder surgery

  This study tests whether two ventilator modes (VCV and PRVC) deliver different amounts of energy to the lungs in adults undergoing laparoscopic gallbladder removal.

  Recruiting Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Yenimahalle, Ankara · NCT07670494

• Fibrinogen-to-Albumin Ratio as a Predictor of ARDS in Traumatic Brain Injury

  This study tests whether the fibrinogen-to-albumin ratio can predict who among adults with traumatic brain injury will develop acute respiratory distress syndrome (ARDS).

  Recruiting Tanta University · Tanta, Gharbia Governorate · NCT07664358

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.