Resilience endotypes and early ARDS detection using biomarkers and AI
Official title: Resilience Endotype-derivation through Parsimonious Analysis and causal Inference of Recovery from Acute Respiratory Distress Syndrome (REPAIR-ARDS)
Funded at Duke University · NIH-11416345 · Data updated 2026-11-12
A Duke University team is using biomarkers and smart data analysis to detect ARDS early and uncover patterns that predict how patients recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 15, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $644,410 |
| NIH project number | 5R01HL170175-02 |
| Project ID | NIH-11416345 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with suspected or confirmed ARDS admitted to the ICU.
✕Less likely to help
Patients without ARDS or those not eligible for ICU-based biomarker testing may not benefit.
What this research studies
In this project, researchers will combine protein biomarkers with clinical data to create tools that identify ARDS early in ICU patients. They will apply streamlined biomarker panels and parsimonious AI methods to predict ARDS onset and aid timely treatment. The study also aims to map resiliency markers and endotypes of ARDS recovery by integrating multiple omics data. This could help clinicians tailor therapies and improve survival for adults with ARDS.
Why it matters
Potential benefit: If successful, patients with ARDS could receive faster, more precise care and potentially better survival.
How similar studies have gone: Prior work shows promise for biomarker-based early ARDS detection, with ongoing research expanding predictive accuracy.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Kamaleswaran, Rishikesan — Duke University
- Study coordinator: Kamaleswaran, Rishikesan
Related research
Other NIH-funded projects on the same topics.
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Understanding immune checkpoints in acute respiratory distress syndrome
This study is looking at how certain immune pathways might affect people with acute respiratory distress syndrome (ARDS) to help create better treatment options and improve care for patients who need long-term breathing support.
-
A new treatment using gut microbiome to help patients with severe lung injury from viruses
This study is exploring a new way to help people with acute respiratory distress syndrome (ARDS) from viral infections by looking at how certain immune cells and gut bacteria can work together to reduce inflammation and improve recovery.
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Identifying ARDS patients who may benefit from paralytics guided by high-frequency clinical data
This grant aims to help doctors figure out which adults with ARDS are most likely to benefit from paralytic medications using detailed bedside data and electronic health records.
-
PAR1’s role in lung lymphatics and a new therapy approach for ARDS
This grant explores how the thrombin receptor PAR1 affects lung lymphatics to understand and ultimately reduce lung injury in ARDS patients.
-
Dead space and inhaled nitric oxide in pediatric ARDS
This project looks at whether measuring dead space and using inhaled nitric oxide can help improve outcomes for children with acute respiratory distress syndrome.
-
Immune, hormone, and muscle energy links to recovery after ARDS
This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.