Pilot test of a power-guided ventilation strategy for adults on VV-ECMO with severe ARDS
Official title: Pilot Trial Evaluating a Mechanical Power Targeted Ventilation Strategy in Adult VV ECMO Patients with Severe ARDS
Funded at University of Virginia · NIH-11354675 · Data updated 2026-11-12
A small, early-phase study will test whether using a specific “mechanical power” target for ventilation in adults on VV-ECMO with severe ARDS is practical and safe for a future larger trial.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | September 8, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $283,500 |
| NIH project number | 1R34HL186224-01 |
| Project ID | NIH-11354675 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+ years) with severe ARDS on VV-ECMO who meet defined enrollment criteria for a future definitive trial.
✕Less likely to help
Patients not on VV-ECMO or without ARDS, or those who do not meet the target enrollment criteria, may not benefit.
What this research studies
This project will collect data to plan a definitive randomized trial comparing low versus high mechanical power-guided ventilation in adults on VV-ECMO for severe ARDS. Researchers will assess how feasible enrollment is, define who should be included, and measure how well clinicians can follow the ventilation targets. They will also monitor sedative, analgesic, and paralytic use to evaluate safety and tolerability of the power-guided approach. The ultimate goal is to determine if the power-target method can be implemented consistently and inform a future larger study.
Why it matters
Potential benefit: If successful, this approach could lead to a more effective ventilation strategy for adults with severe ARDS on VV-ECMO, potentially improving outcomes and reducing complications.
How similar studies have gone: Previous early-phase work on ECMO ventilation strategies supports feasibility, but this study specifically targets a power-guided approach in VV-ECMO and is exploratory.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Lee, Ryan — University of Virginia
- Study coordinator: Lee, Ryan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.