Fibrinogen-to-Albumin Ratio as a Predictor of ARDS in Traumatic Brain Injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will measure fibrinogen and albumin levels within 24 hours of ICU admission for adults with traumatic brain injury and examine how their ratio relates to the development of ARDS during the first week after injury. The goal is to see if the ratio can serve as an early biomarker to identify patients at higher risk. Data will be collected from patients at Tanta University Hospitals and analyzed to explore correlations with ARDS onset, severity, and timing. The study builds on existing evidence that inflammatory and coagulation pathways influence both traumatic injury outcomes and ARDS risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients ≥ 18 years admitted to the ICU with traumatic Brain Injury
* Admission to the ICU within 24 hours of injury.
* Patients will be expected to remain under hospital care for follow-up
* Availability of fibrinogen and albumin measurements within the first 24 hours of ICU admission.
* Informed consent will be obtained from a legally authorized representative.

Exclusion Criteria:

* Preexisting advanced chronic liver disease, nephrotic syndrome, or protein-losing enteropathy.
* Pre-existing ARDS on admission.
* Recipient of albumin, fibrinogen concentrate, or cryoprecipitate before admission sampling.
* Use of anticoagulant or fibrinolytic therapy before admission.
* Active malignancy or severe systemic infection at admission.
* Direct sever lung injury
* Pregnancy
* Refusal of consent

Where it's running

• Tanta University Hospitals
  Tanta, Gharbia Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Eman M Taher, MD
• Email: emantaher6669@gmail.com
• Phone: 01090822808

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.