Condition

Mild Traumatic Brain Injury clinical trials and research

• 37Clinical trials
• 33NIH research projects
• 8Countries

Newest Mild Traumatic Brain Injury clinical trials

All recruiting trials (37)

• Recovery after mild traumatic brain injury in older adults

  This project will follow people 65 and older who had a mild TBI to see how their thinking, physical abilities, mood, and sleep change over the year after injury.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT07569354

• TES HT100 screening for intracranial problems after mild head injury or new neurological symptoms

  This test checks if the TES HT100 can quickly and safely find intracranial problems in adults who come to the emergency department with mild head injury or new non‑traumatic neurological symptoms.

  Recruiting at 2 sites B&B srl · Castel Volturno, CE and 2 other locations · NCT07490418

• Two online brain-training programs to help emotional health after mild TBI

  This study tests two remote brain-training programs to see which better improves emotional health in adults with mild traumatic brain injury and alexithymia.

  Recruiting at 2 sites Hackensack Meridian Health · Indianapolis, Indiana and 2 other locations · NCT07436754

• Cognitive behavioral therapy for insomnia in people with mild traumatic brain injury

  This study will try cognitive behavioral therapy for insomnia (CBT-I) to see if it helps adults with mild traumatic brain injury sleep better and improve daily functioning.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07385105

• Passive neurosensory reintegration training to help recovery after mild traumatic brain injury

  We will try a gentle multisensory therapy called passive neurosensory reintegration training (PNRT) to see if it helps adults with sub-acute or chronic mild traumatic brain injury recover neurosensory and cognitive symptoms.

  Recruiting University of Miami · Miami, Florida · NCT07356167

• Early Intervention for Adults with Ongoing Post-Concussion Symptoms after Mild TBI

  This study tests a package of physical/occupational therapy and telephonic psychoeducation to help adults recover after a mild traumatic brain injury.

  Recruiting University Medical Center Groningen · Groningen · NCT07341074

• Improving thinking after a concussion using gentle brain stimulation plus cognitive training

  This trial will test whether pairing a mild, non-invasive brain stimulation (tDCS) with cognitive training can help adults who still have thinking problems 3–12 months after a mild concussion.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07246993

• Using ultra-high field and metabolic MRI to understand resilience and degeneration in the aging and diseased brain

  This project will try advanced 3T and 7T MRI scans, including sodium and phosphorus imaging, to see if metabolic and connectivity changes explain resilience and degeneration in adults with MS, NMOSD, MOGAD, Alzheimer’s, Parkinson’s, or healthy aging.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT07202494

• Concussion recovery and support program for young adults

  This pilot randomized trial will test whether a six-session online therapy called CRISP helps 18–30-year-olds with concussion-related headaches feel and function better.

  Recruiting at 2 sites Seattle Children's Hospital · Seattle, Washington and 1 other locations · NCT07097792

• Treatment to improve heart rate variability for long-term concussion symptoms

  This trial tests whether a non-invasive heart rate variability biofeedback program can reduce long-term post-concussion symptoms in adults with a history of mild TBI, including veterans and service members.

  Recruiting Phase 2/3 Virginia Commonwealth University · Richmond, Virginia · NCT07071350

• Improving thinking, daily functioning, mood, and sleep after mild traumatic brain injury and PTSD

  This project will test whether adding morning bright light therapy to compensatory cognitive training helps post-9/11 Veterans with mild traumatic brain injury and PTSD think, function, and sleep better compared with a neutral ion generator.

  Recruiting at 2 sites VA Office of Research and Development · San Diego, California and 1 other locations · NCT07055633

• Non-invasive trigeminal nerve stimulation to improve brain fluid flow and slow cognitive decline

  This trial will try mild, non-invasive stimulation of a head nerve (the trigeminal nerve) to see if it improves cerebrospinal fluid flow and waste clearance in adults with recent mild traumatic brain injury and in healthy volunteers.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07044596

• Improving memory symptoms after brain concussion

  This study is testing whether cognitive behavioral therapy or memory training can help adults who have ongoing memory problems after a concussion feel better.

  Recruiting at 7 sites University of British Columbia · Calgary, Alberta and 7 other locations · NCT06956417

• Improving emotion regulation through napping after a concussion

  This study is testing whether taking a 1.5-hour nap can help young adults who recently had a concussion manage their emotions better.

  Recruiting Phase 1 Merrimack College · North Andover, Massachusetts · NCT06883006

• CORE: Cognitive Optimization Through Rehabilitation and Education for persistent concussion symptoms

  This program tests whether cognitive training plus brain-health education can help Veterans and other adults who still have thinking, memory, or attention problems months after a concussion.

  Recruiting at 2 sites University of Washington · Seattle, Washington and 1 other locations · NCT06859996

• Training to improve hearing after mild brain injuries

  This study is testing if special training exercises can help people with mild brain injuries hear better in noisy places.

  Recruiting The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT06628505

• Behavioral treatment for insomnia in military personnel with mild traumatic brain injury

  This study is testing two different types of therapy for insomnia to see which one helps active duty military personnel with mild traumatic brain injury sleep better.

  Recruiting The University of Texas Health Science Center at San Antonio · Fort Cavazos, Texas · NCT06551987

• Improving attention in military personnel with mild traumatic brain injury using brain stimulation and cognitive training

  This study is testing a new way to help Active Duty Service Members and Veterans with mild traumatic brain injury improve their attention by combining brain stimulation with cognitive training.

  Recruiting at 2 sites United States Naval Medical Center, San Diego · San Diego, California and 1 other locations · NCT06413173

• Using quetiapine to help veterans with post concussive syndrome after mild brain injuries

  This study tests if the medication quetiapine can help veterans aged 18-65 recover from post concussive syndrome after mild brain injuries better than standard treatments.

  Recruiting at 2 sites Phase 3 Foundation for Advancing Veterans' Health Research · Albuquerque, New Mexico and 1 other locations · NCT06333990

• App-based vestibular rehabilitation for adults with mTBI-related dizziness

  This trial tests whether an app-based vestibular rehab program helps adults with dizziness from mild traumatic brain injury more than the usual home program.

  Recruiting at 3 sites Mountain Home Research & Education Corporation · Tampa, Florida and 2 other locations · NCT06222450

• Graded aerobic exercise for mild traumatic brain injury

  This study is trying out a special exercise program to see if it can help people with lingering symptoms after a mild brain injury feel better and improve their overall health compared to those getting regular rehab.

  Recruiting at 2 sites Sunnaas Rehabilitation Hospital · Nesoddtangen and 1 other locations · NCT06177509

• Using magnetic stimulation to treat headaches after concussions

  This study is testing if a special type of brain stimulation can help people with chronic headaches after a concussion feel better without the side effects of regular medications.

  Recruiting Phase 1 State University of New York - Upstate Medical University · Syracuse, New York · NCT06112093

• Neurofeedback treatment for light sensitivity in veterans with mild brain injuries

  This study is trying a new neurofeedback treatment to see if it can help veterans with mild brain injuries who are sensitive to light feel better.

  Recruiting VA Office of Research and Development · Boston, Massachusetts · NCT06109909

• Personalized brain stimulation for long-term symptoms after concussion

  This study will try personalized, noninvasive brain stimulation (TMS) to reduce dizziness, headaches, memory problems, and other lasting symptoms in adults aged 18–65 after a concussion.

  Recruiting Phase 2 University of California, Los Angeles · Westwood, Los Angeles, California · NCT06073886

• Predicting which children with a concussion are likely to have lasting symptoms

  This project will see if early symptoms, blood markers, and school and social information can predict which children with a recent concussion will still have symptoms over the first year.

  Recruiting Duke University · Durham, North Carolina · NCT05825027

• Brain stimulation and imaging for children with mild traumatic brain injury

  This study is testing if a type of brain stimulation can help children aged 10-15 recover better from mild traumatic brain injuries by improving their thinking and movement skills.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT05762796

• Improving access to specialty care for concussion patients

  This study is testing a new mobile health program to help concussion patients get better care faster and improve their recovery by allowing them to share their symptoms daily with doctors.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT05741411

• Combining brain stimulation and cognitive training to treat depression after mild brain injuries

  This study is testing if combining brain stimulation with special cognitive training can help people with depression after a mild brain injury feel better.

  Recruiting University of California, San Diego · La Jolla, California · NCT05682677

• Using magnetic pulses to treat impulsivity and suicidal thoughts in veterans with mild brain injuries

  This study is testing if a new treatment using magnetic pulses can help veterans with mild brain injuries reduce impulsivity and suicidal thoughts.

  Recruiting Phase 1 VA Office of Research and Development · Hines, Illinois · NCT05647044

• Exploring the link between mild cognitive impairment and mild traumatic brain injury

  This study is testing if a new brain stimulation treatment can improve memory in people with mild cognitive impairment who have also had a mild traumatic brain injury.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT05446584

• Using rTMS to treat depression in military personnel with mild TBI

  This study is testing two different types of brain stimulation to see if they can help military personnel and veterans with mild brain injuries feel less depressed.

  Recruiting at 3 sites Henry M. Jackson Foundation for the Advancement of Military Medicine · Palo Alto, California and 2 other locations · NCT05426967

• Digital intervention for post-concussion symptoms

  This study is testing a new digital program called GAIN Lite to see if it helps adults with ongoing concussion symptoms feel better compared to regular care.

  Recruiting University of Aarhus · Hammel, Deb´nmark · NCT05233475

• Using a medication to treat headaches after mild brain injuries in military and civilian patients

  This study is testing if a new medication can help people with mild brain injuries and headaches feel better compared to a placebo.

  Recruiting at 2 sites Phase 2 Henry M. Jackson Foundation for the Advancement of Military Medicine · Fort Bragg, North Carolina and 3 other locations · NCT05049057

• Comparing two group wellness programs for people with brain injuries and their caregivers

  This study is testing two different online wellness programs to see if they can help people with brain injuries and Alzheimer's disease, along with their caregivers, feel better and improve their quality of life.

  Recruiting Kessler Foundation · East Hanover, New Jersey · NCT05048966

• Growth hormone therapy for veterans with mild brain injuries and hormone deficiency

  This study is testing if growth hormone therapy can help improve the quality of life for veterans with mild brain injuries and hormone deficiency.

  Recruiting at 5 sites Phase 3 VA Office of Research and Development · Birmingham, Alabama and 15 other locations · NCT04867317

• Examining the link between mild traumatic brain injuries and dementia in veterans

  This study is trying to see if veterans who have had mild traumatic brain injuries are more likely to develop dementia compared to those who haven't had such injuries.

  Recruiting VA Office of Research and Development · Boston, Massachusetts · NCT04124029

• Combining brain stimulation with cognitive training for mild traumatic brain injury

  This study is testing whether combining brain stimulation with attention training can help people with mild traumatic brain injury and PTSD improve their focus and attention.

  Recruiting Northwestern University · Chicago, Illinois and 1 other locations · NCT03819608

NIH-funded research (33)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Mild Traumatic Brain Injury: A High-Tech Look Inside the Brain with Diffusion MRI

  Researchers are using advanced brain imaging to find biological clues in people who have mild traumatic brain injuries.

  NIH research New York University School of Medicine · New York, United States · NIH-11450398

• How neuromodulation may help headaches after a mild brain injury

  A small study tests whether stimulating the brain with a noninvasive technique can lessen persistent headaches in people who recently had a concussion.

  NIH research Upstate Medical University · Syracuse, United States · NIH-11441465

• New ways to treat chronic pain after mild brain injuries

  A research team is studying why some people develop long-lasting pain after a mild head injury and how brain inflammation contributes to it.

  NIH research Rlr VA Medical Center · Indianapolis, United States · NIH-11418233

• Retraining brain pathways to boost thinking after a mild head injury

  A clinical trial tests a brain-training program to improve thinking and memory in people who have had a mild traumatic brain injury (mTBI).

  NIH research Perception Dynamics Institute · Encinitas, UNITED STATES · NIH-11406497

• Neurobehavioral effects of childhood brain injuries and addiction risk in twins

  This grant studies how mild traumatic brain injury in childhood might influence behavior and the chance of developing addictive behaviors later in life, using twins to understand what’s due to injury versus other factors.

  NIH research Washington University · Saint Louis, United States · NIH-11377341

• Understanding and improving reactive balance after mild traumatic brain injury

  This grant tests how people recover their balance after a mild brain injury and how targeted training could help prevent falls.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11348157

• Lateral habenula circuit dysfunction in mild traumatic brain injury

  Researchers are studying how mild traumatic brain injury affects a brain region called the lateral habenula and may contribute to depression, anxiety, and related mood problems, using mouse models to understand potential treatments.

  NIH research Henry M. Jackson Fdn for the Adv Mil/med · Bethesda, United States · NIH-11347176

• Neurofeedback for light sensitivity after mild traumatic brain injury

  This project uses a gentle neurofeedback brain-stimulation method to try to reduce light sensitivity in people with mild traumatic brain injury.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11334098

• How mild head injury changes brain cells that control rhythms

  Researchers are looking at how mild head injuries change specific brain cells that control brain rhythms and touch sensitivity, with the goal of helping people after concussion.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11322120

• How mild head injuries affect children's behavior, thinking, mental health, brain scans, and genes

  Researchers are using long-term brain scans, behavior tests, and genetic data from children to learn how mild head injuries affect thinking, behavior, and mental health.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11312612

• Sodium MRI to measure brain sodium in mild traumatic brain injury

  Using an improved sodium MRI scan alongside diffusion MRI to measure brain sodium in people with mild traumatic brain injury (concussion) to find imaging markers.

  NIH research New York University School of Medicine · New York, United States · NIH-11308698

• Detecting brain changes in veterans with mild traumatic brain injury

  This study is looking for new ways to see how mild brain injuries affect thinking and brain health in veterans, using advanced imaging techniques and tests to help improve their treatment and care.

  NIH research VA San Diego Healthcare System · San Diego, United States · NIH-11286777

• Using balance training to wake up cerebellum circuits and help thinking after mild head injury

  This project uses balance training in a mouse model of mild traumatic brain injury to change cerebellum circuits with the goal of improving thinking and balance for people with TBI.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11239783

• Non‑invasive vagus nerve stimulation for veterans with mild traumatic brain injury

  This work uses a handheld device that stimulates the vagus nerve through the skin to try to ease symptoms in veterans with mild traumatic brain injury, often alongside PTSD.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11239769

• New approaches for long-term pain after repeated mild head injuries

  The project looks at whether blocking a brain inflammation pathway can reduce long-term pain after repeated mild head injuries in people of different ages and sexes.

  NIH research Rlr VA Medical Center · Indianapolis, United States · NIH-11220687

• Understanding Brain Changes After Childhood Head Injury and Addiction Risk

  This project looks at how mild head injuries in childhood might affect brain development and increase the chance of addiction later on.

  NIH research Washington University · Saint Louis, United States · NIH-11141893

• Non-invasive treatment for veterans with mild traumatic brain injury

  This study is looking at a new, easy-to-use device that gently stimulates a nerve in the neck to help veterans with Mild Traumatic Brain Injury and PTSD feel better and improve their brain health without needing surgery.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11091429

• Effects of long-term fentanyl use after mild brain injuries in veterans

  This study is looking at how long-term use of fentanyl might impact veterans with mild brain injuries from blasts, focusing on how it relates to anxiety and substance use, and it hopes to find ways to help by testing a specific gene in mice.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11083153

• Investigating the effects of mild traumatic brain injury in children

  This study is looking at how mild traumatic brain injuries (like concussions) affect kids aged 0-11, comparing their behavior and thinking skills to other kids who have had different injuries or no injuries at all, to help us understand how these injuries might impact their growth and development.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11082517

• Understanding and treating metabolic issues in the brain after mild traumatic injuries

  This study looks at how mild brain injuries can impact brain health by affecting the blood-brain barrier and causing metabolic problems, with the goal of finding new treatments that could help people recover better after such injuries.

  NIH research University of Kentucky · Lexington, United States · NIH-11077863

• Using advanced MRI techniques to study sodium levels in mild brain injuries

  This study is looking at how new MRI techniques can help us understand brain changes in people with Mild Traumatic Brain Injury (MTBI) by measuring sodium levels, which could lead to better treatments for this common condition.

  NIH research New York University School of Medicine · New York, United States · NIH-11058399

• A new treatment for light sensitivity after mild brain injuries

  This study is testing a new way to help people with mild traumatic brain injuries who are sensitive to light, using a gentle brain stimulation technique to see if it can make their symptoms better and improve their daily life.

  NIH research VA Boston Health Care System · Boston, United States · NIH-10988286

• Understanding hearing problems after mild traumatic brain injury

  This study is looking into the hearing problems people might have after a mild brain injury, like trouble hearing clearly or dealing with ringing in the ears, to better understand what causes these issues and help improve treatment for those affected.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-10986133

• Effects of mild traumatic brain injury on behavior and addiction risk in adolescents

  This study is looking at how mild traumatic brain injuries (like concussions) can affect kids and teens over time, especially in relation to the risk of developing addiction, and it’s designed for families with twins to help us understand these effects better.

  NIH research Washington University · Saint Louis, United States · NIH-10933538

• New treatments for chronic pain from mild brain injuries

  This study is looking at how mild concussions, which many older veterans experience, can lead to long-lasting pain and inflammation in the brain, and it hopes to find new ways to help those dealing with chronic pain from these injuries.

  NIH research Rlr VA Medical Center · Indianapolis, United States · NIH-10932964

• Improving cognitive and balance functions through targeted training in a mouse model of brain injury

  This study is looking at how balance training might help improve thinking skills and recovery in mice with mild brain injuries, which could lead to new treatments for veterans and others who have experienced similar injuries.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-10929450

• How mild traumatic brain injury affects neurodegeneration in older adults

  This study is looking at how mild traumatic brain injuries, which many Veterans experience, might affect memory and brain health over time, especially in relation to conditions like Alzheimer's disease, to help understand how these injuries can lead to cognitive decline.

  NIH research VA Boston Health Care System · Boston, United States · NIH-10919799

• Investigating brain changes related to cognitive status after mild traumatic brain injury

  This study is looking at how mild traumatic brain injuries can change the brain's structure and affect thinking skills, and it involves patients getting MRI scans to help us understand these changes better over time.

  NIH research New York University School of Medicine · New York, United States · NIH-10896341

• Improving cognitive skills after a mild brain injury

  This study is testing a new training program called PATH that helps people recover their thinking skills after a mild brain injury, like a concussion, by improving how they process visual information.

  NIH research Perception Dynamics Institute · Encinitas, UNITED STATES · NIH-10864051

• Impact of low-level blast exposure on fear responses in rats with brain injuries

  This study looks at how repeated mild blasts affect how rats learn to feel fear and get over it, helping us understand how similar injuries might lead to mental health problems like PTSD in veterans.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-10856919

• Investigating how mild traumatic brain injury affects blood vessels in the brain related to Alzheimer's disease.

  This study is looking at how mild brain injuries might affect blood vessel health in the brain and increase the risk of dementia, using mice to help us understand what happens after such injuries, so we can find new ways to protect brain health.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-10844392

• Detecting brain changes in veterans with mild traumatic brain injury

  This study is looking for new ways to spot brain changes in veterans who have had mild traumatic brain injuries, using advanced imaging techniques to help doctors better understand their condition and improve their treatment.

  NIH research VA San Diego Healthcare System · San Diego, United States · NIH-10842273

• Investigating how a specific protein affects brain cells after repeated mild injuries

  This study is looking at how a protein in brain cells reacts after repeated mild brain injuries, using mice to find out if these changes can help or hurt recovery, with the hope of discovering new treatments for people affected by such injuries.

  NIH research Roskamp Institute, INC. · Sarasota, United States · NIH-10739968

Related topics

Quick answers

How many Mild Traumatic Brain Injury clinical trials are recruiting right now?

37, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (31 trials), Norway (1 trial), Netherlands (1 trial), Denmark (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 2: 3, Phase 3: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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