Warrior CARE: Cannabis Behavioral Health
Official title: Wayne Warrior CAnnabis Research and Education: Cannabis and Behavioral Health
Run by Wayne State University · NCT06381180 · Data updated 2026-11-12
This study tests whether different cannabis compounds (THC, CBD, or THC+CBD) or placebo can help veterans with PTSD and suicidal thoughts over 12 weeks.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 19 Years to 69 Years |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Wayne State University Academic / other |
| Locations | 1 site (Detroit, Michigan) |
| Status | Recruiting |
| Started | September 22, 2025 |
| Main results expected | December 31, 2030 |
| Study ends | December 31, 2030 |
| Registry record updated | August 7, 2026 |
| Trial ID | NCT06381180 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are veterans aged 19-69 with PTSD (CAPS-5 score ≥25) who have used cannabis in the past year and are not seeking treatment for Cannabis Use Disorder.
✕Probably not a fit
Individuals without PTSD, those not using cannabis, or those at high immediate suicide risk may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized, controlled trial enrolling veterans with PTSD who use cannabis or are interested in trying it. Participants are assigned to THC, CBD, THC+CBD, or placebo and will use their assigned cannabis dose daily for 12 weeks. Weekly assessments track mood, behavior, and cannabis use, while a lab component measures cognition, fear conditioning, and PTSD-related factors. The trial aims to understand the potential therapeutic effects and safety of cannabinoids in this population.
Why it matters
Potential benefit: If successful, the study could clarify whether specific cannabis components help reduce PTSD symptoms and suicidality in veterans.
How similar studies have gone: Earlier studies with cannabinoids in PTSD have shown mixed results; this trial adds a structured, randomized design focused on veterans with suicidality.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * a healthy veteran who has served in a branch of the US armed forces * report using cannabis within the past year * currently meet DSM-5 criteria for PTSD and a score of 25 or greater on the CAPS-5 (the anchor, or index, trauma does not have to be related to military service) * between the ages of 19-69 years old * not seeking treatment for Cannabis Use Disorder * stable (i.e., under the care of a physician or therapist and not experiencing acute symptoms) on psychotropic medications and/or psychotherapy before the study begins (participants can be in treatment for PTSD) * agree to adhere to study procedures Exclusion Criteria: * pregnant, lactating, or heterosexually active women and not using medically approved birth control * current or past bipolar or psychotic disorder as determined using the SCID-5 * at immediate high risk for suicide based on the C-SSRS * current SUD other than Nicotine Use Disorder and Alcohol Use Disorder (mild or moderate) * allergies and/or other contradictions for using cannabis * any clinically significant medical problems * systolic/diastolic BP \>140/90 mmHg or systolic BP \<95 mmHg * elevated liver function tests * exhibit cognitive impairment (\<80 IQ) * enrolled in another clinical trial or have received any drug as part of a research study within 30 days of dosing * used a prescription medication (with the exception of birth control) within 14 days of study entry that in the opinion of the medically responsible investigator will interfere with the safety of the participant or the study results * unable to provide informed consent
Where it's running
-
Wayne State University
Detroit, Michigan, United States Recruiting
Study contacts
- Study coordinator: Leslie Lundahl, PhD
- Email: llundahl@wayne.med.edu
- Phone: 3139931374
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Brain imaging to predict teens' response to cannabis treatment
This project will test whether teens' brain activity during a learning task can predict how well 14–17-year-olds do in a 10-week virtual reward program to reduce cannabis use.
-
Registry for improving mental health care in the Maritimes
This study is trying to improve mental health care for people with depression in the Maritimes by creating a registry that helps track treatments and outcomes while involving those who have experienced these challenges.
-
Friends and family training for those at risk of suicide
A six-week program tests whether training for caregivers can help them support a loved one at risk of suicide while also taking care of their own mental health.
-
Anger, Social Thinking, and PTSD in French Veterans
This study tests whether PTSD in former French military personnel is linked to higher anger through changes in social thinking abilities.
-
TSND-201 treatment for PTSD in adults
This study tests two doses of TSND-201 or placebo to see if it helps adults with PTSD.
-
Co-Adaptation of a Digital Pain Program for Canadian Veterans
We’re testing whether a self-guided digital pain management program, delivered through the Manage My Pain app, is acceptable and useful for Canadian Veterans with chronic pain.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.