Testing a medication to improve cognitive function and reduce PTSD symptoms in Veterans
Randomized Placebo-Controlled Trial of Methylphenidate for the Treatment of Post-Traumatic Stress Disorder with Associated Neurocognitive Complaints
This study is looking at whether a medication called methylphenidate, often used for ADHD, can help improve thinking skills and reduce PTSD symptoms in Veterans, especially those who also have mild brain injuries. If you’re a Veteran dealing with these issues, you might be able to join and see if this medication works for you!
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Puget Sound Healthcare System NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11204585 on NIH RePORTER |
What this research studies
This research investigates the effects of methylphenidate, a medication commonly used for ADHD, on cognitive function and PTSD symptoms in Veterans. The study will involve a randomized placebo-controlled trial, where participants will receive either the medication or a placebo to assess its effectiveness. The goal is to determine if methylphenidate can help alleviate cognitive complaints and improve overall functioning in Veterans suffering from PTSD, particularly those with comorbid mild traumatic brain injury. Participants will be closely monitored throughout the trial to evaluate changes in their symptoms and cognitive abilities.
Who could benefit from this research
Good fit: Ideal candidates for this research are Veterans diagnosed with PTSD, especially those experiencing cognitive complaints and possibly having mild traumatic brain injury.
Not a fit: Patients without a diagnosis of PTSD or those not experiencing cognitive difficulties may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option for Veterans with PTSD and cognitive difficulties, potentially improving their quality of life.
How similar studies have performed: Previous pilot studies have shown promising results for the use of methylphenidate in improving cognitive function and reducing PTSD symptoms, suggesting potential for success in this larger trial.
Where this research is happening
Seattle, United States
- VA Puget Sound Healthcare System — Seattle, United States (Active)
Researchers
- Principal investigator: Hendrickson, Rebecca Cappel — VA Puget Sound Healthcare System
- Study coordinator: Hendrickson, Rebecca Cappel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.