Using eTMS to treat PTSD in veterans and first responders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the safety and efficacy of an EEG personalized Transcranial Magnetic Stimulation (eTMS) approach for veterans and first responders diagnosed with PTSD. Participants will undergo extensive physiological and behavioral testing before and after the eTMS application, including MRI, EEG, and various behavioral assessments. The study is designed as a double-blind, sham-controlled, parallel group, randomized trial to ensure robust results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Veteran or first responder
* diagnosed with post-traumatic stress disorder with PCL-5 cutoff of 31 or above

Exclusion Criteria:

* Claustrophobia
* Contraindications to MRI
* Pregnant
* Uncontrolled medical, psychological, or neurological conditions
* Unable to calculate EEG alpha frequency
* History of ECT or rTMS
* History of intracranial lesion or increased intracranial pressure
* History of stroke
* History of other neurologic conditions
* Family history of epilepsy
* Personal history of epilepsy
* certain medications

Where it's running

• Fralin Biomedical Research Institute
  Roanoke, Virginia, United States Recruiting

Study contacts

• Principal investigator: Wynn Legon, PhD — Virginia Polytechnic Institute and State University
• Study coordinator: Jessica Florig, MPH
• Email: jnw@vtc.vt.edu
• Phone: 540-526-2261

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Anger, Social Thinking, and PTSD in French Veterans

  This study tests whether PTSD in former French military personnel is linked to higher anger through changes in social thinking abilities.

  Recruiting Direction Centrale du Service de Santé des Armées · Draguignan · NCT07851090

• TSND-201 treatment for PTSD in adults

  This study tests two doses of TSND-201 or placebo to see if it helps adults with PTSD.

  Recruiting at 9 sites Phase 3 Transcend Therapeutics · Denver, Colorado and 8 other locations · NCT07836647

• Long-term outcomes after Hyperbaric Oxygen Therapy in veterans with TBI, PCS, or PTSD

  This study tests whether benefits from HBOT persist over time for veterans with brain injury or related conditions.

  Recruiting Phase 2 Summit Hyperbarics and Wellness · Boise, Idaho · NCT07732374

• SEE FAR CBT for Adults With PTSD

  This 12-week, one-on-one SEE FAR CBT program tests a trauma-focused therapy to see if PTSD symptoms improve in adults 18 and older.

  Recruiting Community Stress Prevention Center · Kiryat Shmona · NCT07720674

• Brief SEE FAR CBT: a short, focused therapy for adults with PTSD

  A 6-session Brief SEE FAR CBT treatment is tested against usual dynamic psychotherapy for adults with PTSD to see if it reduces symptoms.

  Recruiting Community Stress Prevention Center · Sha'ar Hanegev · NCT07710573

• MDMA Therapy for PTSD in Veterans

  This phase 2 study tests a fixed 120 mg dose of MDMA, followed by a 60 mg supplemental dose, plus therapy, to see if it helps adults who are veterans with PTSD.

  Recruiting Phase 2 Sunstone Medical · Rockville, Maryland · NCT07569159

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.