Using eTMS to treat PTSD in veterans and first responders
Electroencephalogram (EEG) Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder (PTSD)
This study is testing a new brain treatment called eTMS to see if it can help veterans and first responders with PTSD feel better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Virginia Polytechnic Institute and State University Academic / other |
| Locations | 1 site (Roanoke, Virginia) |
| Trial ID | NCT06294106 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the safety and efficacy of an EEG personalized Transcranial Magnetic Stimulation (eTMS) approach for veterans and first responders diagnosed with PTSD. Participants will undergo extensive physiological and behavioral testing before and after the eTMS application, including MRI, EEG, and various behavioral assessments. The study is designed as a double-blind, sham-controlled, parallel group, randomized trial to ensure robust results.
Who should consider this trial
Good fit: Ideal candidates for this study are veterans or first responders who have been diagnosed with PTSD.
Not a fit: Patients with contraindications to MRI, uncontrolled medical conditions, or a history of certain neurological issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could significantly improve PTSD symptoms in veterans and first responders.
How similar studies have performed: While the approach of using eTMS is innovative, similar studies have shown promise in treating PTSD with neuromodulation techniques.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Veteran or first responder * diagnosed with post-traumatic stress disorder with PCL-5 cutoff of 31 or above Exclusion Criteria: * Claustrophobia * Contraindications to MRI * Pregnant * Uncontrolled medical, psychological, or neurological conditions * Unable to calculate EEG alpha frequency * History of ECT or rTMS * History of intracranial lesion or increased intracranial pressure * History of stroke * History of other neurologic conditions * Family history of epilepsy * Personal history of epilepsy * certain medications
Where this trial is running
Roanoke, Virginia
- Fralin Biomedical Research Institute — Roanoke, Virginia, United States (Recruiting)
Study contacts
- Principal investigator: Wynn Legon, PhD — Virginia Polytechnic Institute and State University
- Study coordinator: Jessica Florig, MPH
- Email: jnw@vtc.vt.edu
- Phone: 540-526-2261
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.