Working memory training to improve fear extinction in veterans with PTSD
Identifying Clinically Relevant Neural Circuit Mechanisms of Cognitive Control Training for PTSD
This study is testing if a special memory training program can help veterans with PTSD learn to manage their fears better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | VA Office of Research and Development Federal |
| Locations | 1 site (San Diego, California) |
| Trial ID | NCT06629064 on ClinicalTrials.gov |
What this trial studies
This study tests whether a working memory training (WMT) program can enhance fear extinction learning and its neural mechanisms in veterans diagnosed with posttraumatic stress disorder (PTSD). The approach involves conducting eight remote training sessions over four weeks, alongside MRI scans to assess changes in brain activity. By linking working memory capabilities to fear extinction, the study aims to provide insights that could improve existing PTSD treatments, particularly exposure therapy. The research supports the Department of Veteran Affairs' mission to develop effective treatment strategies for veterans suffering from PTSD.
Who should consider this trial
Good fit: Ideal candidates for this study are veterans who meet DSM-5 criteria for PTSD and are fluent in English.
Not a fit: Patients with a history of severe mental health disorders, acute suicidality, or significant neurological issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve treatment outcomes for veterans with PTSD by enhancing their ability to process and overcome traumatic memories.
How similar studies have performed: Previous studies have shown that working memory training can positively influence fear extinction in civilian populations, suggesting potential for success in this veteran-focused approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Fluent in English * Meet current DSM-5 criteria for Posttraumatic Stress Disorder * Are willing to attend 8 total remote sessions of working memory training over course of four weeks * Are willing to attend MRI scans pre and post working memory training * 4-week stability on pharmacological and psychosocial treatments Exclusion Criteria: * A lifetime history of psychotic disorders, lifetime history of bipolar disorder * Past-year severe substance use and severe alcohol use disorder. Mild-to-moderate alcohol use disorder will be allowed to enhance generalizability in our sample due to the high comorbidity of alcohol use and PTSD * History of any neurological disorder that might be associated with cognitive dysfunction (e.g., cerebrovascular accident, intracranial surgery, aneurysm, seizure disorder) * Acute suicidality requiring immediate clinical intervention * Moderate to severe traumatic brain injury (TBI). However, mild to moderate levels of TBI (mTBI) will be included. * Receiving benzodiazepines or medications with anticholinergic effects that may affect fear learning measures * Inability to safely complete fMRI session (i.e., metal in body, medical implants)
Where this trial is running
San Diego, California
- VA San Diego Healthcare System, San Diego, CA — San Diego, California, United States (Recruiting)
Study contacts
- Principal investigator: Daniel M Stout, PhD — VA San Diego Healthcare System, San Diego, CA
- Study coordinator: Daniel M Stout, PhD
- Email: Daniel.Stout@va.gov
- Phone: (858) 642-3944
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.