Working memory training to improve fear extinction in veterans with PTSD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study tests whether a working memory training (WMT) program can enhance fear extinction learning and its neural mechanisms in veterans diagnosed with posttraumatic stress disorder (PTSD). The approach involves conducting eight remote training sessions over four weeks, alongside MRI scans to assess changes in brain activity. By linking working memory capabilities to fear extinction, the study aims to provide insights that could improve existing PTSD treatments, particularly exposure therapy. The research supports the Department of Veteran Affairs' mission to develop effective treatment strategies for veterans suffering from PTSD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Fluent in English
* Meet current DSM-5 criteria for Posttraumatic Stress Disorder
* Are willing to attend 8 total remote sessions of working memory training over course of four weeks
* Are willing to attend MRI scans pre and post working memory training
* 4-week stability on pharmacological and psychosocial treatments

Exclusion Criteria:

* A lifetime history of psychotic disorders, lifetime history of bipolar disorder
* Past-year severe substance use and severe alcohol use disorder. Mild-to-moderate alcohol use disorder will be allowed to enhance generalizability in our sample due to the high comorbidity of alcohol use and PTSD
* History of any neurological disorder that might be associated with cognitive dysfunction (e.g., cerebrovascular accident, intracranial surgery, aneurysm, seizure disorder)
* Acute suicidality requiring immediate clinical intervention
* Moderate to severe traumatic brain injury (TBI). However, mild to moderate levels of TBI (mTBI) will be included
* Receiving benzodiazepines or medications with anticholinergic effects that may affect fear learning measures
* Inability to safely complete fMRI session (i.e., metal in body, medical implants)

Where it's running

• VA San Diego Healthcare System, San Diego, CA
  San Diego, California, United States Recruiting

Study contacts

• Principal investigator: Daniel M Stout, PhD — VA San Diego Healthcare System, San Diego, CA
• Study coordinator: Daniel M Stout, PhD
• Email: Daniel.Stout@va.gov
• Phone: (858) 642-3944

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Non-invasive vagus nerve stimulation (gammaCore) for PTSD

  This study will test whether the handheld gammaCore device, which delivers mild electrical stimulation to the vagus nerve through the neck, can help adults with PTSD reduce their symptoms.

  Recruiting Acacia Clinics · Sunnyvale, California · NCT07523685

• Non‑trauma PTSD treatment for veterans and service members with mild or moderate TBI

  This pilot will test a non‑trauma psychotherapy program to help veterans and service members with mild or moderate traumatic brain injury who have PTSD.

  Recruiting The University of Texas Health Science Center at San Antonio · Fort Hood, Texas · NCT07351305

• NightWare use for cardiovascular health in women with PTSD-related nightmares

  This study tests whether NightWare can improve heart and kidney health biomarkers in premenopausal women who have PTSD-related nightmares.

  Recruiting at 2 sites University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT07021014

• Psilocybin-assisted therapy for PTSD after sexual assault

  This trial will test whether a single 25 mg oral dose of psilocybin combined with therapy helps cisgender women who have PTSD from a sexual assault.

  Recruiting Phase 2 Sunstone Medical · Rockville, Maryland · NCT06902974

• Short-term therapy for PTSD symptoms

  This study is testing a week-long therapy to see if it can help adults with PTSD feel better and reduce their symptoms.

  Recruiting Ben-Gurion University of the Negev · Beersheba · NCT06826937

• Augmented reality-enhanced exposure therapy for PTSD in U.S. military personnel

  This tests whether adding augmented reality to standard exposure therapy helps U.S. military veterans and active-duty adults with PTSD.

  Recruiting Wayne State University · Charleston, South Carolina · NCT06740487

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.