Condition

Alcohol Drinking clinical trials and research

• 40Clinical trials
• 40NIH research projects
• 5Countries

Newest Alcohol Drinking clinical trials

All recruiting trials (40)

• See if stopping alcohol can lower blood pressure and heart risk in adults who drink and have hypertension

  This study tests whether abstaining from alcohol for 8 weeks can improve blood pressure and heart-health markers in adults who regularly drink and have high blood pressure.

  Recruiting The University of Texas at Arlington · Arlington, Texas · NCT07783061

• Alcohol, Breast Milk, and Metabolism in Lactating Women

  This study tests whether breast tissue locally metabolizes alcohol by comparing alcohol-related markers in blood and breast milk from lactating women after low-level alcohol exposure.

  Recruiting University of Illinois at Urbana-Champaign · Urbana, Illinois · NCT07779967

• Targeting alcohol-opioid co-use among young adults with a new mobile health tool

  A mobile health app is being tested to help young adults reduce drinking and opioid use when they occur together.

  Recruiting Brown University · Providence, Rhode Island · NCT07663448

• Ketogenic Diet and Alcohol Intoxication: Can ketosis affect brain function and alcohol response

  This study tests whether a 4‑week ketogenic diet changes how the brain works and how the body handles alcohol in adults who drink regularly.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07602270

• Reset Challenge: See if 30 days without alcohol reduces high-risk drinking

  This 30-day mobile program tests whether people who drink heavily can cut back or stop drinking for a month, with a focus on those in Oklahoma.

  Recruiting University of Oklahoma · Tulsa, Oklahoma · NCT07591428

• Acute effects of Jägerbombs with energy drinks during a binge for healthy adults

  This study tests whether mixing Jägermeister with an energy drink during a binge affects intoxication, mood, coordination, and sleepiness compared with alcohol alone in healthy adults who regularly drink caffeinated beverages.

  Recruiting Fundació Institut Germans Trias i Pujol · Barcelona · NCT07588022

• Microbiota Interventions for Accelerated Aging in People with HIV on Alcohol

  This study tests whether two safe dietary supplements—Limosilactobacillus reuteri and blueberry extract—can affect immune aging markers in people with HIV who recently used alcohol.

  Recruiting Phase 1/2 Louisiana State University Health Sciences Center in New Orleans · New Orleans, Louisiana · NCT07462767

• Reducing alcohol and trying a probiotic to improve thinking and brain glucose use in older high-risk drinkers

  This study will test whether reducing alcohol with motivational interviewing plus taking a blinded probiotic or placebo can improve thinking and brain glucose metabolism in people ages 65–84 who drink heavily.

  Recruiting University of Miami · Miami, Florida · NCT07415707

• Motivational interviewing chatbot to help high-risk drinkers cut back on alcohol

  This project tests whether a motivational interviewing chatbot app can help adults who drink at high risk reduce their alcohol use over four weeks.

  Recruiting Yonsei University · Seoul, Seoul · NCT07238998

• Using dynamic visual noise to reduce alcohol cravings and drinking in college students

  This study will test whether watching brief moving black-and-white square videos (dynamic visual noise) can lower alcohol cravings and drinking in college students who experience cravings at least once a week.

  Recruiting University of Wyoming · Laramie, Wyoming · NCT07157124

• How alcohol changes the social brain during paired interactions

  This study tests whether drinking alcohol changes brain activity and social bonding during conversations between pairs of regular social drinkers aged 21–30.

  Recruiting University of Illinois at Urbana-Champaign · Champaign, Illinois and 1 other locations · NCT07125534

• Intervention for heavy drinking in young adults

  This study tests a new program that helps young adults aged 18-25 who drink heavily by using online counseling and mobile tools to encourage them to drink less.

  Recruiting Northeastern University · Boston, Massachusetts · NCT06994962

• Examining alcohol use in romantic relationships

  This study is testing how drinking alcohol affects couples' relationships by having them drink either alcohol or non-alcoholic drinks and then answer questions about their relationship over time.

  Recruiting Carnegie Mellon University · Pittsburgh, Pennsylvania · NCT06822257

• Therapy for HIV-positive individuals with hazardous drinking

  This study is testing if a new therapy combined with a short alcohol intervention can help people with HIV who drink too much to reduce their alcohol use and improve their overall health.

  Recruiting Syracuse University · Syracuse, New York · NCT06648629

• Comparing mobile health screening to traditional methods for early detection of oral cancer in rural Varanasi.

  This study tests if using mobile health screenings can help find oral cancer earlier than traditional methods for people living in rural Varanasi.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT06535867

• Pilot intervention for HIV patients focusing on alcohol use and medication effects

  This study tests a new program to help HIV-positive patients who drink alcohol manage their medications better and reduce risks like falls and memory problems.

  Recruiting Phase 1 Yale University · West Haven, Connecticut · NCT06513819

• Understanding and preventing binge drinking among students

  This study is testing different ways to help college students reduce binge drinking by understanding what influences their drinking habits.

  Recruiting University Hospital, Caen · Caen · NCT06447350

• Text messaging strategies to reduce binge drinking in military personnel

  This study is testing if sending text messages can help young Air Force trainees drink less and avoid problems related to binge drinking.

  Recruiting University of Virginia · San Antonio, Texas · NCT06318975

• Telehealth program using blood tests to help treat alcohol use disorder

  This study is testing a new telehealth program that uses blood tests to help people with alcohol use disorder by combining online therapy with rewards for submitting their test results.

  Recruiting Washington State University · Spokane, Washington · NCT06265506

• Alcohol's effects on men's condom resistance and sexual risk

  This project tests whether alcohol and partner mood influence young single men's likelihood to resist using condoms and behave aggressively during sex.

  Recruiting Arizona State University · Phoenix, Arizona · NCT06158880

• Smartphone app to help university students with binge drinking

  This study is testing a smartphone app to help university students aged 18 to 25 who binge drink learn to manage their alcohol use better.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens, Picardie · NCT06084832

• Understanding how alcohol affects decision-making in people with PTSD

  This study tests how drinking alcohol affects decision-making in adults with PTSD to see if it helps us understand their relationship with alcohol use and improve treatment options.

  Recruiting University of Texas at Austin · Austin, Texas · NCT06002633

• Motivating bystanders to prevent sexual assault and reduce alcohol use

  This study is testing a new program to see if it can help young adults step in to prevent sexual assault and reduce their alcohol use.

  Recruiting University of Nebraska Lincoln · Lincoln, Nebraska · NCT05873413

• Understanding how alcohol affects young adults with bipolar disorder

  This study looks at how alcohol affects young adults with bipolar disorder compared to their peers to see if it leads to problems with drinking over time.

  Recruiting University of Texas at Austin · Austin, Texas · NCT05838274

• Reducing alcohol use among pregnant women

  This study is testing whether a special program that helps pregnant women cut down on drinking alcohol works better than regular prenatal care alone.

  Recruiting New York University · Houston, Texas · NCT05766761

• Examining how alcohol affects sexual decision-making and testing an intervention

  This study tests how drinking alcohol affects sexual choices and tries a new method to help men who have sex with men make safer decisions about sex.

  Recruiting Boston University Charles River Campus · Boston, Massachusetts · NCT05729256

• Testing a wearable device to measure alcohol levels in real-world settings

  This study is testing a new wearable device that measures alcohol levels in your body to see how accurately it works in everyday situations.

  Recruiting University of Illinois at Urbana-Champaign · Champaign, Illinois · NCT05692830

• Investigating how stress affects impulsivity and alcohol use in African Americans using fMRI

  This study tests how stress affects impulsivity and drinking habits in African Americans using brain scans to see if stereotype threat plays a role.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT05675332

• Online program for young adults about alcohol and health

  This study is testing an online program to see if it helps young adults make better choices about alcohol and sexual health compared to just answering surveys.

  Recruiting University of Washington · Seattle, Washington · NCT05620849

• Web-based intervention for military spouses to reduce alcohol use

  This study tests a new online program designed to help military spouses cut down on alcohol use and encourage their service member partners to seek help.

  Recruiting Stanford University · Palo Alto, California · NCT05619185

• Reducing blood pressure in mid-life adults who binge drink

  This study is testing whether an 8-week exercise program can help mid-life adults who binge drink lower their blood pressure and improve their overall health.

  Recruiting The University of Texas at Arlington · Arlington, Texas · NCT05522075

• Examining how cannabis affects alcohol consumption

  This study is testing how different types of cannabis affect drinking habits in heavy drinkers who use cannabis regularly.

  Recruiting Phase 2 Brown University · Providence, Rhode Island · NCT05389930

• Culturally grounded alcohol intervention for First Nation communities

  This study is testing a new alcohol intervention designed with and for a First Nation community to see if it helps people better manage their drinking while respecting their cultural background.

  Recruiting University of Rhode Island · Fredericton, New Brunswick · NCT05363878

• Using probiotics to reduce heart disease risk in people with HIV who drink heavily

  This study is testing if a probiotic pill can help improve gut health and lower heart disease risk in people with HIV who drink heavily.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05288790

• Using brain stimulation to reduce alcohol cravings

  This study is testing if a type of brain stimulation can help people with alcohol use disorder reduce their cravings and drinking behavior.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT04998916

• Alcohol use screening in pregnancy with a questionnaire and a blood test

  This project will test whether a short self-report questionnaire (T-ACE) can reliably detect high alcohol use in pregnant women by comparing answers with a blood biomarker (phosphatidylethanol).

  Recruiting University Hospital, Lille · Lille · NCT04786587

• Using a ketone ester to reduce alcohol consumption in people with alcohol use disorder

  This study is testing if a special drink made from ketones can help people with alcohol use disorder drink less by changing how their brains react to alcohol.

  Recruiting Phase 2/3 University of Pennsylvania · Philadelphia, Pennsylvania · NCT04616781

• Impact of COVID-19 on Alcohol Use and Related Issues

  This study is looking to see how the COVID-19 pandemic has changed drinking habits and related issues for people, especially those with alcohol use problems, over a couple of years.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04391816

• Promoting health behavior change in adolescents using interactive narratives

  This study is testing a new interactive program that helps teenagers change their health habits, especially around alcohol use, to see if it can make them healthier during their doctor visits.

  Recruiting University of California, San Francisco · San Francisco, California · NCT04110756

• Exploring how genetic variations affect alcohol response

  This study is testing how genetic differences affect how people respond to alcohol and whether smoking changes that response, involving adults aged 21 to 60.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03294460

NIH-funded research (40)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Inhibitory Corticostriatal Circuits and Binge Drinking

  This grant studies how specific brain circuits inhibit or promote binge drinking, with the goal of identifying targets to help people who struggle with alcohol use.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11426848

• How X chromosome differences may influence alcohol drinking in mice

  This project looks at how sex chromosomes, especially the X chromosome, might affect alcohol drinking behavior and related brain signals in mice, with the goal of informing human understanding and future therapies.

  NIH research Miami University Oxford · Oxford, United States · NIH-11404942

• Estrogen’s quick signals and binge drinking in female mice

  A study in female mice explores how fast, membrane-based estrogen signals influence brain circuits to drive binge alcohol drinking, with the goal of finding new ways to reduce excessive alcohol use.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11395371

• Corticolimbic brain circuits and stress coping linked to alcohol use

  This research looks at how brain circuits that control stress responses affect drinking behavior, with a focus on differences between males and females.

  NIH research University of New Mexico · Albuquerque, United States · NIH-11391074

• ADHD and adolescent drinking: how teen alcohol use affects thinking and behavior

  A study with teens and young adults who have ADHD will look at how alcohol exposure during adolescence influences thinking, attention, and behavior.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11380733

• Histone tweaks in brain cells linked to resilience against compulsive drinking

  This NIH grant explores how changes in histone acetylation in specific brain cells may protect people from developing compulsive drinking behaviors.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11346510

• Stress and brain circuits behind how we respond to alcohol

  A study in adult rodents will explore how stress changes the way the brain processes alcohol’s unpleasant effects and increases drinking, focusing on a specific brain pathway.

  NIH research Tufts University Medford · Boston, UNITED STATES · NIH-11343464

• Dopamine signals in the frontal brain and persistent alcohol drinking

  This work looks at how dopamine signals in a decision-making part of the brain may drive heavy, punishment-resistant drinking to help people with alcohol use disorder.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11330292

• How the brain chemical norepinephrine affects binge drinking and alcohol's unpleasant effects

  Researchers are seeing whether norepinephrine signals in the brainstem change binge drinking and the unpleasant reactions to alcohol in ways that could help people who binge drink.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11326635

• How stress-related brain systems change alcohol drinking and relapse

  This research is testing whether two brain systems — the dynorphin/kappa opioid system and oxytocin — change how stress makes people with alcohol problems drink more and relapse.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11306585

• Brain circuit changes in the prefrontal cortex linked to compulsive drinking

  This project looks at how repeated alcohol use rewires brain connections that weaken control over drinking for people with alcohol problems.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11306578

• How a stress-related brain chemical in the amygdala area affects heavy drinking

  This work looks at whether a brain chemical called PACAP in a stress-related brain area helps drive heavy drinking and anxiety in people with alcohol use disorder.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11295773

• Brain circuits that drive escalating and binge drinking

  This project looks at how specific brain circuits change with heavy or binge drinking to help people with alcohol use disorder.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11238476

• Exercise and biological samples to understand alcohol-related liver disease

  A patient-focused program from Cleveland Clinic aims to study alcohol-related liver disease by collecting blood, urine, saliva, and PBMC samples from patients and from heavy drinkers and healthy controls.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11232483

• Reducing alcohol drinking with a drug that targets actin in the brain

  A study tests a new drug that blocks a key brain motor protein to help people reduce alcohol drinking and prevent relapse.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11231843

• How fast-acting estrogen signals influence binge drinking in females

  This work looks at whether quick estrogen signals in the brain change binge drinking, especially in females.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11184440

• Brain circuits tying stress coping to later alcohol use

  This work is looking at whether boosting a natural brain chemical (called 2‑AG) and strengthening a specific brain circuit can help poor stress coping and reduce later alcohol drinking, with attention to male–female differences.

  NIH research University of New Mexico · Albuquerque, United States · NIH-11162472

• How social stress and brain immune responses can increase alcohol drinking

  This work looks at how social stress might change immune activity in stress‑sensitive brain areas and make people more likely to drink heavily after stressful social situations.

  NIH research Northwestern University · Chicago, United States · NIH-11158870

• How sex chromosomes affect alcohol drinking

  This research looks at whether having one versus two X chromosomes changes alcohol drinking and relapse, which could help explain why men and women experience alcohol problems differently.

  NIH research Miami University Oxford · Oxford, United States · NIH-11145036

• Brain connections linking drinking and anxiety in females and males (animal study)

  This project looks at specific front-insula brain circuits that may drive compulsive alcohol drinking and anxiety, with attention to differences between females and males.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11124752

• How teen drinking affects thinking and behavior in ADHD

  Researchers are using a genetic mouse model to learn how alcohol exposure during the teen years might worsen attention, self-control, and later drinking problems in people with ADHD.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11123397

• How brain circuits affect stress coping and alcohol use

  This study looks at how people with PTSD handle stress and how that might lead them to drink alcohol, focusing on specific parts of the brain that could help us find better ways to support coping strategies.

  NIH research University of New Mexico · Albuquerque, United States · NIH-11088538

• How social stress affects alcohol drinking behavior

  This study looks at how feeling stressed in social situations might lead some people, especially those who feel less socially connected, to drink more alcohol to feel better, and it hopes to find out how this happens in the brain so we can help those at risk for drinking problems.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11087906

• Understanding how brain circuits influence alcohol drinking behavior

  This study is looking at how certain brain cells affect drinking habits, especially how people might start drinking to feel better during tough times, and it’s designed for anyone interested in understanding more about the reasons behind alcohol use and addiction.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11085926

• Investigating how brain signals affect alcohol drinking behavior

  This study is looking at how signals in the brain related to dopamine affect drinking habits, using mice to see how their brain responses change when they drink alcohol repeatedly, with the hope of finding new ways to help people who struggle with alcohol use.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11060049

• Investigating how brainstem norepinephrine affects binge drinking and taste aversion.

  This study is looking at how certain parts of the brain affect binge drinking and how the body reacts to alcohol, with the goal of finding new ways to help people who struggle with drinking too much.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11042245

• Investigating brain changes related to compulsive alcohol drinking

  This study is looking at how drinking alcohol repeatedly affects the brain, especially a part that helps control drinking habits, to find out what happens in the brain that makes some people crave alcohol and have trouble thinking clearly, with the hope of discovering new ways to help those dealing with alcohol addicti

  NIH research University of Texas Dallas · Richardson, United States · NIH-11019844

• Investigating how a brain circuit affects alcohol drinking in people with chronic pain and opioid withdrawal.

  This study is looking at how chronic pain and alcohol use are connected, especially for people dealing with pain or recovering from opioid use, to help understand how their brain affects drinking habits and improve future treatments.

  NIH research Washington University · Saint Louis, United States · NIH-10999148

• How estrogen affects alcohol drinking behavior in women

  This study looks at how the hormone estrogen affects drinking habits in women who might be more likely to struggle with alcohol use, using female mice to learn more about how it works in the brain, with the hope of finding new ways to help women who drink too much.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10981991

• How adolescent alcohol drinking affects cognition and behavior in individuals with ADHD

  This study looks at how drinking alcohol during the teenage years might affect thinking and behavior in young people with ADHD, using a special mouse model to see if heavy drinking makes ADHD symptoms worse.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-10932376

• Investigating how brain regions affect alcohol drinking and anxiety in male and female rats

  This study looks at how brain activity and anxiety affect drinking habits in male and female rats to help us understand alcohol use disorder better, which could lead to more personalized treatments for people dealing with alcohol-related challenges.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-10931348

• How social stress affects alcohol drinking behavior

  This study looks at how feeling stressed in social situations might lead some people to drink more alcohol, especially those who feel lower in social status, and it aims to understand the brain's role in this behavior to help find ways to prevent drinking problems.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10922854

• Investigating how brain immune cells influence alcohol drinking behavior.

  This study is looking at how certain brain cells called microglia might affect drinking habits, especially after experiencing stress early in life, to help us understand why some people may be more likely to develop problems with alcohol later on, which could lead to better ways to prevent and treat alcohol use issues.

  NIH research Duke University · Durham, United States · NIH-10906135

• Improving HIV prevention for high-risk adults in East Africa who drink alcohol

  This study is all about finding better ways to help adults at high risk of HIV, especially those who often visit bars, in East Africa, by creating friendly and effective ways to encourage them to get involved in HIV prevention and treatment while also tackling issues like heavy drinking.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10901942

• How sex chromosomes affect alcohol drinking behaviors

  This study looks at how being male or female might change the way animals drink alcohol, focusing on the role of their genes, especially those linked to the X chromosome, to help us understand why men and women might drink differently.

  NIH research Miami University Oxford · Oxford, United States · NIH-10855841

• Using Neuropeptide S to reduce anxiety and alcohol consumption

  This study is looking at how a substance called Neuropeptide S might help people with alcohol dependence feel less anxious and drink less, especially during withdrawal, which could lead to new treatments for those struggling with alcohol use.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10838740

• How traumatic stress affects alcohol drinking in men and women

  This study is looking at how stress from trauma affects drinking habits in men and women differently, using animal models to explore the brain's role in this relationship, with the goal of helping people who struggle with both PTSD and alcohol use.

  NIH research Oregon Health & Science University · Portland, United States · NIH-10832582

• Investigating how brain immune cells respond to repeated alcohol exposure

  This study is exploring how drinking alcohol affects the brain's immune cells, called microglia, and will use a special imaging tool to see how these cells react over time, helping us understand why some people may drink more alcohol.

  NIH research Yale University · New Haven, United States · NIH-10704077

• Understanding how brain changes affect alcohol drinking behavior

  This study looks at how drinking too much alcohol affects a part of the brain that helps with decision-making about drinking, and it aims to understand why some people keep drinking even when it’s harmful, which could lead to new ways to help those struggling with alcohol use.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10675458

• Exploring how social and environmental factors influence high-risk drinking in college students

  This study looks at how things like bullying and discrimination affect college students' drinking habits, aiming to understand why some students drink more than others based on their backgrounds.

  NIH research University of San Francisco · San Francisco, United States · NIH-10438453

Related topics

Quick answers

How many Alcohol Drinking clinical trials are recruiting right now?

40, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (34 trials), France (3 trials), South Korea (1 trial), Canada (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 2: 2, Phase 2/3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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