Building Ukraine's strength in PTSD treatment
Fostering Ukraine's Capacity in the Delivery and Research of Innovative Evidence-based PTSD Treatment
This project will try the Reconsolidation of Traumatic Memories (RTM) protocol alongside standard PTSD treatments to see if it reduces symptoms in adults with PTSD living in Ukraine.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University of Luxembourg Academic / other |
| Locations | 2 sites (Kyiv and 1 other locations) |
| Trial ID | NCT07318181 on ClinicalTrials.gov |
What this trial studies
The Lux4UA project implements the short RTM protocol and compares it with guideline treatments (TF-CBT, EMDR, and SSRI medication) at clinical sites in Kyiv. Trained clinicians deliver RTM in typically three to five sessions, and patients are followed with standardized measures such as the PCL-5 to track symptom change, function, and dropout. The project includes therapist training and capacity-building to support delivery and research of evidence-based trauma care in the Ukrainian humanitarian context. Findings will inform whether RTM is a feasible, faster alternative to longer trauma-focused therapies for civilians, displaced persons, and military personnel.
Who should consider this trial
Good fit: Adults aged 18–65 who are residents of Ukraine with a DSM-5-TR or ICD-11 diagnosis of PTSD or clinically significant PTSD symptoms are the intended participants.
Not a fit: People with acute comorbid psychiatric disorders, severe cognitive impairment, inability to consent, or those already receiving other parallel PTSD treatments may not benefit from or be eligible for participation.
Why it matters
Potential benefit: If successful, RTM could provide faster relief from PTSD symptoms with fewer sessions and less need to retell traumatic events.
How similar studies have performed: Prior small randomized and clinical reports have shown promising, often rapid symptom reductions with RTM in a few sessions, but large-scale replication in diverse settings is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. being adults 18-65 years, 2. having a diagnosis of PTSD determined by DSM-5-TR or ICD-11 and/or 3. having PTSD symptoms causing clinically significant distress or impact on social, occupational, or other areas of functioning, as defined by the PTSD Checklist PCL-5, 4. being a resident of Ukraine. Exclusion Criteria: 1. having any other acute comorbid mental health conditions, 2. receiving any other parallel PTSD treatment, 3. being unable to provide informed consent, having severe cognitive impairment, or being otherwise unlikely to adhere to study procedures.
Where this trial is running
Kyiv and 1 other locations
- National Psychological Association of Ukraine — Kyiv, Ukraine (Recruiting)
- Veteran Mental Health and Rehabilitation Center 'Forest Glade' Ministry of Health of Ukraine — Kyiv, Ukraine (Recruiting)
Study contacts
- Principal investigator: Viktoriia V Gorbunova, ScD — University of Luxembourg
- Study coordinator: Viktoriia V Gorbunova, ScD
- Email: viktoriia.gorbunova@uni.lu
- Phone: +352621749295
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.