Testing a medication to help Veterans with PTSD and recent strokes.

A randomized placebo-controlled trial of methylphenidate in Veterans with a diagnosis of post traumatic stress disorder and recent cerebral stroke.

['FUNDING_OTHER'] · BIRMINGHAM VA MEDICAL CENTER · NIH-10975942

This study is looking at whether a medication called methylphenidate can help Veterans who have both PTSD and have recently had a stroke feel better and function more easily in their daily lives.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorBIRMINGHAM VA MEDICAL CENTER (nih funded)
Locations1 site (BIRMINGHAM, UNITED STATES)
Trial IDNIH-10975942 on ClinicalTrials.gov

What this research studies

This research investigates the effects of methylphenidate (MPH) on Veterans who have both post-traumatic stress disorder (PTSD) and have recently experienced a stroke. The study aims to determine if MPH can alleviate PTSD symptoms and improve daily functioning after a stroke. Participants will be randomly assigned to receive either MPH or a placebo, and their progress will be monitored over time. The goal is to find effective treatments that address both PTSD and post-stroke recovery simultaneously.

Who could benefit from this research

Good fit: Ideal candidates are Veterans diagnosed with PTSD who have experienced a cerebral stroke within the past 1 to 12 months.

Not a fit: Patients who do not have PTSD or have not experienced a recent stroke may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide a new treatment option that improves mental health and recovery outcomes for Veterans with PTSD and stroke.

How similar studies have performed: Previous research has shown that MPH can be effective in treating PTSD symptoms, but this specific approach in stroke patients is novel.

Where this research is happening

BIRMINGHAM, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.