Investigating the role of gut serotonin transport in PTSD
Official title: Role of intestinal serotonin transporter in post traumatic stress disorder
Funded at Jesse Brown VA Medical Center · NIH-10856911 · Data updated 2026-11-12
This study is looking at how the gut's serotonin transporter might affect PTSD symptoms in veterans, hoping to find new ways to help treat this condition by understanding the connection between gut health and serotonin levels.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01BX006177-02 |
| Project ID | NIH-10856911 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans experiencing PTSD symptoms, particularly those who have not responded well to current treatments.
✕Less likely to help
Patients without a diagnosis of PTSD or those who do not have a history of trauma may not benefit from this research.
What this research studies
This research explores how the serotonin transporter in the gut may influence post-traumatic stress disorder (PTSD), particularly in veterans. It aims to understand the relationship between gut microbiota and serotonin levels, which could affect symptoms of PTSD. Using a specialized mouse model, the study will examine how changes in serotonin transport in the gut may contribute to the development or worsening of PTSD symptoms. The goal is to identify new therapeutic targets for more effective treatments.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for PTSD, improving outcomes for patients.
How similar studies have gone: While the role of serotonin in PTSD has been studied, the specific focus on gut serotonin transport and its implications for PTSD treatment is relatively novel.
Where this research is happening
-
Jesse Brown VA Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Gill, Ravinder K — Jesse Brown VA Medical Center
- Study coordinator: Gill, Ravinder K
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.