Condition
Anxiety Disorders clinical trials and research
Research outlook What's coming for Generalized anxiety disorder: the next 6 months to 5 yearsAs of November 12, 2026, Find a Trial lists 70 Anxiety Disorders clinical trials that are recruiting, at sites in 19 countries (most in United States (33), Canada (7), China (7)). 1 was first registered in the last 30 days. By phase: Phase 2 (4), Phase 2/3 (1), Phase 3 (1), Phase 4 (1). The most active sponsors are Massachusetts General Hospital (4), National Institutes of Health Clinical Center (CC) (4), University of Calgary (2). There are also 16 NIH-funded research projects on Anxiety Disorders, with $8.3 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 70Clinical trials
- 16NIH research projects
- 1New in 30 days
- 19Countries
Newest Anxiety Disorders clinical trials
All recruiting trials (70)
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Understanding anxiety, depression, and bipolar disorder over time in China
This study tests how anxiety, depressive, and bipolar symptoms change over three years to find patterns that help with earlier recognition and prediction in people aged 12–55.
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See if personalized CBM-I can help anxious kids ages 10–17
Aimed at youth with Generalized, Separation, or Social Anxiety, the study tests a personalized cognitive bias modification for interpretation (CBM-I) to see if it reduces threat-focused thinking and anxiety.
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Expectancy Focused Exposure for Anxiety Disorders
We test whether Expectancy Focused Exposure helps reduce anxiety symptoms and prevent fear from coming back better than Anxiety Focused Exposure in adults with anxiety disorders.
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Does extra family income improve child mental health and brain biology in low-income families?
This study tests whether three years of extra income for parents can improve their child’s mental health and neuroimmune function.
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Parent group program using the Unified Protocol for teens with autism and anxiety/depression
This trial tests a parent-guided adaptation of the Unified Protocol to help adolescents with autism and co-occurring anxiety or depression.
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AI-guided cognitive behavioral therapy for depression and anxiety
This program will try an AI-guided online CBT to see if it helps adults with mild depression or anxiety.
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MOCHA: Inpatient Mental Health Care for High-Risk Pregnancy
This study tests a collaborative mental health program for pregnant or recently postpartum patients hospitalized for medical problems to see if it can be delivered feasibly and acceptably.
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Digital stepped-care mindfulness program for emotional disorders
This project tests whether adding an online mindfulness program to usual care helps adults (18–65) with depression, anxiety, OCD, or PTSD recover faster and stay well longer.
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Qigong and multicomponent exercise for people with panic disorder
This trial will test whether a Qigong-based multicomponent exercise program can reduce panic symptoms in adults diagnosed with panic disorder.
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In-person vs. videochat vicarious exposure for fear of spiders
This study will test whether a single session of in-person exposure, videochat-based vicarious exposure, or no treatment reduces fear and disgust in people with a fear of spiders.
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Touchminds: Help-seeking for teens with anxiety
A web-based program tests whether six self-guided modules plus three live video sessions help adolescents with anxiety decide to seek professional help.
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SoundHeal multi-sensory integrative therapy for detained youth with emotional dysregulation
This program will test whether SoundHeal's multi-sensory therapy can help detained youth (ages 12–18) better manage emotional dysregulation, depression, anxiety, and stress.
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Exercise effects on brain biomarkers in adults with anxiety
This program will test whether a structured exercise routine changes brain-derived biomarkers (mitochondrial LAC and inflammatory IL-6) in sedentary adults with generalized, social, or panic anxiety.
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Mindfulness and body-awareness program for postpartum anxiety
This study will test a 4-week mindfulness-based program to see if it helps mothers in the first year after delivery with anxiety improve emotion regulation and awareness of bodily signals.
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Closed-loop brain neurofeedback on the left prefrontal cortex to lower stress-related heart responses in people with coronary heart disease and anxiety.
This trial will test whether closed‑loop fNIRS neurofeedback aimed at the left dorsolateral prefrontal cortex can lower heart rate during a cold‑pain stress test in adults with stable coronary heart disease and anxiety.
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Closed-loop neurofeedback targeting the right prefrontal cortex to improve heart regulation in people with coronary heart disease and anxiety
This trial will try real-time fNIRS neurofeedback aimed at the right dorsolateral prefrontal cortex to lower sympathetic heart activity and improve heart rate variability in right-handed adults with stable coronary heart disease and DSM-5 anxiety.
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Creating Health online course for people with rheumatological conditions
This project will test whether an online course about diet and self-care helps adults with rheumatoid arthritis, Sjogren's syndrome, lupus, mixed connective tissue disease, or psoriatic arthritis reduce fatigue and improve quality of life.
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Fluoxetine added to immunotherapy for advanced liver and gallbladder cancer with depression or anxiety
This trial will test whether adding the antidepressant fluoxetine to standard PD-1/PD-L1 immunotherapy helps people with advanced liver or gallbladder cancers who also have depression or anxiety.
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Ultra-brief digital help while waiting for psychotherapy
This trial tests different versions of a short online program (UKADO) to help adults with depression or anxiety who are waiting for outpatient psychotherapy.
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Online parent education to help manage anxiety in 2–7-year-old children
This trial will test whether brief, self-guided online education for parents of children aged 2–7 helps them better manage their child's anxiety.
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Personalized digital treatment for adolescent anxiety using the Sidekick app
This project will test whether adding the Sidekick smartphone app to regular outpatient therapy helps adolescents (13–18) with anxiety carry out exposure exercises and find the blended approach acceptable.
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Cannabidiol-assisted learning to help manage generalized anxiety
This trial will test whether adding FDA-approved cannabidiol (Epidiolex) to brief cognitive behavioral therapy helps adults 18–45 with generalized anxiety disorder improve emotion regulation and reduce anxiety symptoms.
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EGR2 and NLRP3 pathways in sleep apnea-related thinking and mood problems
This study will test whether activity in the EGR2 and NLRP3 inflammation pathways is linked to thinking, memory, and mood problems in children and adults with obstructive sleep apnea compared with healthy volunteers.
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Comparing brief psychoanalytic and emotionally focused couple therapies for relationship distress
This trial will test whether brief psychoanalytic couple therapy or emotionally focused therapy better reduces relationship problems and related depression and anxiety in heterosexual couples with moderate to severe relationship distress.
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Mindful Self-Compassion delivered in person versus by video for anxiety and depression
This project will see if an 8-week Mindful Self-Compassion class delivered in person or by video helps people with anxiety or depression have fewer symptoms.
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Mindfulness therapy for chronic insomnia with anxiety
This study is testing whether a mindfulness therapy combined with sleep tips can help people aged 8 and older with chronic insomnia and anxiety sleep better and feel less anxious.
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Preventive behavioral intervention for young adults with psychotic experiences
This study is testing if a new Resilience Training program can help college freshmen and sophomores who are at risk for serious mental illnesses feel better and prevent issues like psychosis, mood swings, and anxiety.
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AI-COA®: using AI to measure depression and anxiety severity from video interviews
This will test whether an AI tool can reliably measure depression and anxiety severity from video interviews in adults who have just started a new treatment.
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Improving patient engagement in collaborative care for anxiety and depression
This study is testing a new way to involve patients more in their anxiety and depression treatment by using their personal goals to see if it makes them and their doctors happier with the care they receive.
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Brain stimulation for anxiety and depression in children and teens
This program will try transcranial magnetic stimulation (TMS) to see if it reduces anxiety and depression in children and teens aged 6 to 18 who are referred by their doctors.
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Comparing Islamic and Standard Hypnotherapy for Anxiety and Depression
This study is testing whether a special type of hypnotherapy that incorporates Islamic principles can help Muslim adults with anxiety and depression feel better compared to standard hypnotherapy.
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Evaluating mentalization-based psychotherapy for anxiety and depression
This study is testing a new group therapy called mentalization-based psychotherapy to see if it helps people with anxiety and depression feel better compared to standard therapy.
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Effects of Ericksonian Hypnotherapy on Anxiety
This study is testing whether Ericksonian hypnotherapy can help people with Generalized Anxiety Disorder feel less anxious and change their brain activity.
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Using a smartphone app for exposure therapy in anxiety disorders
This study is testing whether using a smartphone app can make exposure therapy more effective for people with anxiety compared to traditional therapy alone.
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Exposure therapy for anxiety in older adults
This study is testing if exposure therapy from trained nurses can help older adults with anxiety feel better and improve their quality of life.
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Identifying genetic markers for SSRI-induced behavioral activation in youth
This study is trying to find genetic markers that can help predict which children and teens with depression or anxiety might experience increased energy or restlessness from taking certain antidepressants.
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Internet-based treatment for anxiety and depression in adolescents
This study is testing an online treatment for anxiety and depression in Romanian teenagers aged 13-17 to see if it helps them feel better and to find out which teens are most likely to benefit from it.
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Gaze-Contingent Music Therapy to Help Kids with Anxiety
This study is testing if adding a special music therapy to regular talk therapy can help kids and teens with anxiety feel better.
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Cognitive Behavioural Therapy for youth with mood and anxiety disorders
This study is testing a new type of Cognitive Behavioural Therapy called CBT-MyOWL for young people aged 14-19 with mood and anxiety disorders to see if it helps them stick with treatment and feel better compared to standard therapy.
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Imagery rescripting treatment for OCD and BDD
This study is testing a new therapy called imagery rescripting to see if it can help people with Obsessive Compulsive Disorder and Body Dysmorphic Disorder feel better and change their negative thoughts.
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Brief treatment for anxiety and PTSD in South Africa
This study is testing a new, simple treatment for anxiety and PTSD in South Africa to see if it helps people feel better compared to regular care.
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Using focused ultrasound to help treat anxiety disorders
This study is testing whether focused ultrasound can help people with anxiety by changing how their brain works during emotional tasks.
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Cognitive training for anxiety, depression, and PTSD
This study is testing a brain training program to see if it can help people with anxiety, depression, or PTSD think more clearly and feel better.
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Comparing Sertraline and Placebo for Treating Anxiety in Children with Neurodevelopmental Disorders
This study is testing if the medication sertraline can help reduce anxiety in children and teens aged 8-17 with neurodevelopmental disorders like autism and Fragile X syndrome compared to a placebo.
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Home use of ketamine for chronic conditions
This study is testing whether taking ketamine at home can help people with chronic pain, depression, or PTSD feel better and improve their symptoms.
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Telehealth intervention for anxiety in young children with autism
This study is testing a new online therapy called DINOSAUR to see if it can help reduce anxiety in young children with autism.
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Evaluating Ketamine Treatment Plans for Chronic Conditions
This study is testing different ways to use Ketamine for people with chronic pain, depression, and anxiety to see how well it works and if combining it with therapies like talk therapy or music helps improve their conditions.
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Investigating brain responses to threats in anxiety and depression
This study is testing how an anti-anxiety medication affects the brain's response to threats in people with anxiety, depression, or both to better understand their differences and improve treatments.
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Developing a group treatment to help teens at risk for serious mental illness
This study is testing a new group program to help high school students with mild signs of depression or anxiety build resilience and prevent serious mental health issues.
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Using near-infrared technology to monitor anxiety and provide feedback.
This study is testing a new way to monitor anxiety in real-time and provide feedback to help people with generalized anxiety disorder feel better through a special technology.
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Comparing two school programs to help autistic students with anxiety
This study is testing two school programs to see which one helps autistic kids aged 8-14 manage anxiety and improve their emotions better.
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Improving therapy for veterans with PTSD and anxiety
This study is testing whether individual or group therapy can help veterans and service members with PTSD and anxiety feel better compared to regular care.
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Combining neurostimulation with emotion regulation training for emotional issues
This study is testing if combining brain stimulation with training on how to manage emotions can help people with emotional issues feel better.
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Mindful Self-Compassion training for anxiety and depression
This study is testing if an 8-week Mindful Self-Compassion training program can help people with anxiety and depression feel better compared to those who don't take the training.
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Using RxWell to Reduce Opioid Use After Knee or Hip Surgery
This study is testing whether a digital tool called RxWell can help people with mood disorders who are having knee or hip surgery reduce their opioid use and improve their mental health after the operation.
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Evaluating personalized medication based on genetic testing for psychiatric disorders
This study is testing if giving personalized medication advice based on your genes can help people with mood, anxiety, or psychotic disorders feel better compared to regular medication dosing.
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Understanding children's emotions in therapy
This study is testing a new therapy approach for kids aged 8 to 15 with anxiety, depression, trauma, or behavior issues to see if it helps them feel better compared to those who aren't receiving treatment right away.
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Blended (online + in-person) versus face-to-face transdiagnostic group therapy for anxiety and depression
This trial will try whether a blended program (online modules plus group sessions) helps adults with anxiety or depression as much as traditional face-to-face group therapy.
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Investigating how CBT affects brain circuits in anxiety
This study is trying to see how Cognitive Behavioural Therapy (CBT) changes brain activity in people with anxiety to help improve treatment options.
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Exploring factors influencing anxiety and depression
This study looks at how different thoughts, feelings, biology, and social support affect anxiety and depression to help improve treatment for those struggling with these conditions.
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Comparing two therapies for treating anxiety disorders
This study is testing two different therapies for anxiety to see which one helps people feel less anxious and improve their mental health better than just learning about anxiety.
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EMDR therapy for young children with trauma and anxiety
This study is testing if EMDR therapy can help young children aged 3 to 6 who are dealing with trauma and anxiety feel better.
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Using a device to change how people cope with anxiety
This study is testing if a device that uses magnetic pulses can help people with anxiety learn to cope better with their feelings.
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Adapting a brief online intervention for youth anxiety in diverse cultures
This study is testing a brief online program to help reduce anxiety in children aged 4-10 from diverse cultural backgrounds, focusing on making it relevant for Latin and Haitian families.
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Investigating brain response variability to predict success in online therapy for mental health
This study is testing if changes in brain activity can help predict how well online therapy works for people with depression, anxiety, and insomnia.
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Understanding who benefits most from different psychotherapies for depression and anxiety
This study tests how people with depression or anxiety respond to individual therapy, group therapy, or internet-based CBT to help clinicians tailor care.
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Identifying genetic factors in children affected by antidepressant side effects
This study is trying to find out if certain genes can help predict which children might have negative side effects from antidepressants, so doctors can better manage their treatment.
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Developing MRI techniques to study mood and anxiety disorders
This study is testing new MRI techniques to see how the brains of people with mood and anxiety disorders work compared to healthy individuals.
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Evaluation of patients with mood and anxiety disorders and healthy volunteers
This study is looking for people with mood and anxiety disorders, as well as healthy volunteers, to see if they can help with research that aims to better understand these conditions.
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Examining brain function in children with anxiety disorders
This study is testing how brain function in kids with anxiety disorders changes after they receive either therapy or medication, to see if it helps improve their symptoms.
NIH-funded research (16)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Doula support to improve mood and anxiety health for rural mothers
A rural-focused program tests whether birth doulas can boost confidence, support, and maternal health for new mothers with mood and anxiety concerns.
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Molecular and brain circuits linked to anxiety disorders
A researcher is studying a specific brain circuit to understand what drives anxiety and how it could be treated for people with anxiety disorders.
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Parent-child trio study of pediatric anxiety disorders
A family-based genetic study aims to identify DNA factors that contribute to anxiety disorders in children.
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Genetics of anxiety disorders: how genes influence risk and treatment need
This NIH grant looks at how our genes influence anxiety disorders like generalized anxiety and panic, with findings that could lead to better risk prediction and new treatments.
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How attention-related brain networks develop from birth through early school age and relate to childhood anxiety
Researchers are following children from birth through early school age to learn whether early attention brain systems are linked to later anxiety.
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Improving Short Treatments for Anxiety and PTSD in South Africa
This project explores a quick, new way to help people in South Africa who experience anxiety and PTSD in local health clinics.
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Stepped care for pregnancy-related mood and anxiety for women with HIV in Kenya
This project brings routine mental-health screening, brief counseling, and remote psychiatric care together to help pregnant and postpartum women living with HIV in Kenyan clinics who have depression or anxiety.
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Genes linked to anxiety and related conditions
This project looks for genetic differences that help explain why some adults develop anxiety disorders.
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Understanding the challenges women face with mood and anxiety disorders during and after pregnancy
This study looks at how common mood and anxiety disorders are for women during and after pregnancy, and how these issues affect their healthcare and delivery experiences, with the aim of finding ways to improve mental health support for all women, especially those facing challenges based on their background or financia
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Understanding brain patterns in anxiety disorders and their comorbidities
This study is looking at how certain brain patterns might help us understand and predict the severity of multiple anxiety disorders in people, so we can find better ways to treat those who are dealing with more than one type of anxiety.
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How children's brain development relates to anxiety disorders from birth to school age
This study is looking at how children's brains develop attention skills from birth to school age, especially in kids who might be at risk for anxiety, to find early signs that could help us prevent or treat anxiety issues later on.
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Improving mental health care for pregnant women living with HIV in Kenya
This study is looking to help women living with HIV in Kenya who are dealing with mood and anxiety issues during and after pregnancy by adding mental health support to their regular healthcare visits.
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A brief treatment for anxiety disorders and PTSD in South Africa
This study is testing a new, shorter treatment for anxiety and PTSD that can be used in regular doctor’s offices in South Africa, making it easier for people to get the help they need.
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Understanding brain responses to errors in children with anxiety
This study is looking at how kids aged 9-12 with anxiety disorders react to mistakes they make during tasks, to help find ways to better understand and treat anxiety in young people.
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Investigating how Medicare's Quality Payment Program affects treatment for depression and anxiety in primary care.
This study looks at how a program that pays doctors affects the way they screen and treat depression and anxiety in older adults on Medicare, with the goal of making it easier for them to get the mental health care they need.
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Improving anxiety treatment while reducing benzodiazepine use in patients taking opioids
This study is looking for people who take both anxiety medications (benzodiazepines) and pain medications (opioids) to see if a special online therapy program can help them safely reduce their anxiety meds while also checking in on their pain and anxiety levels over 12 weeks.
Related topics
Quick answers
How many Anxiety Disorders clinical trials are recruiting right now?
70, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 19 countries. The most sites are in United States (33 trials), Canada (7 trials), China (7 trials), Spain (4 trials), Turkey (Türkiye) (4 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 4, Phase 2/3: 1, Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.