Pimavanserin for Sleep Problems in Veterans with PTSD
Official title: Pimavanserin for Insomnia in Veterans with Post-traumatic Stress Disorder
Funded at Michael E Debakey VA Medical Center · NIH-11591888 · Data updated 2026-11-12
This grant supports Dr. Melissa Jones to study a new medicine, pimavanserin, to help veterans with PTSD sleep better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michael E Debakey VA Medical Center NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | October 1, 2022 |
| Project end | September 30, 2027 |
| Funding year | 2027 |
| NIH project number | 5IK2CX002363-05 |
| Project ID | NIH-11591888 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are veterans with PTSD experiencing significant insomnia who could participate in a clinical trial.
✕Less likely to help
Patients without PTSD or insomnia may not benefit from this specific intervention.
What this research studies
A veteran-focused research effort is being planned to see if pimavanserin can improve sleep in people with PTSD. The project will include training Dr. Jones in clinical trial design, biostatistics, and how to measure insomnia and PTSD symptoms. The work aims to translate this approach into future trials that could help veterans experience better sleep and overall functioning.
Why it matters
Potential benefit: If successful, this work could lead to better sleep and quality of life for veterans with PTSD.
How similar studies have gone: Prior studies in this area show promise for targeted sleep aids, but this exact approach is being explored in this veteran population.
Where this research is happening
-
Michael E Debakey VA Medical Center
Houston, United States Active
Researchers
- Principal investigator: Jones, Melissa Beth — Michael E Debakey VA Medical Center
- Study coordinator: Jones, Melissa Beth
Related research
Other NIH-funded projects on the same topics.
-
A new sleep-help approach for Veterans with PTSD
A new ACT-based insomnia treatment tailored for Veterans with PTSD aims to improve sleep and quality of life.
-
Acceptance-based sleep program for Veterans with PTSD
This program combines behavioral sleep techniques with Acceptance and Commitment Therapy to help Veterans with PTSD who have chronic insomnia.
-
A new treatment for insomnia in veterans with PTSD
This study is testing a new way to help veterans with PTSD who have trouble sleeping by combining helpful sleep habits with a special therapy called Acceptance and Commitment Therapy, to see if it can improve their sleep quality.
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Using Pimavanserin to improve sleep in veterans with PTSD
This study is looking at how the medication Pimavanserin, usually used for Parkinson's disease, can help veterans with PTSD sleep better and feel less anxious, and it’s being led by Dr. Melissa Beth Jones.
-
Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure
A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.
-
DESCANSO: A friendly CBT plan to ease depression, sleep problems, and fatigue in Latino cancer patients
A Spanish-speaking CBT program called DESCANSO is being tested to help Latino cancer patients feel less tired, sleep better, and happier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.