Biobank for studying ALS and Alzheimer's diseases
NYSCF Scientific Discovery Biobank
This study is collecting blood, skin samples, and health information from people to see how genetics might help us understand and find treatments for ALS and Alzheimer's disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 30 Days and up |
| Sex | All |
| Sponsor | New York Stem Cell Foundation Research Institute Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT06203106 on ClinicalTrials.gov |
What this trial studies
The New York Stem Cell Foundation (NYSCF) Research Institute is conducting research to advance understanding of various diseases by creating stem cells from biological samples such as skin or blood. This observational study involves collecting health questionnaires, biological samples, and saliva for genetic analysis. The aim is to explore genetic factors and develop potential treatments or cures for conditions like ALS and Alzheimer's disease. Participants may also be contacted for future studies based on their contributions.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 30 days or older with a diagnosis of ALS, Alzheimer's disease, or related conditions, as well as healthy controls.
Not a fit: Patients who do not have a relevant diagnosis or genetic background related to the diseases of interest may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in treatments or cures for ALS, Alzheimer's disease, and other neurodegenerative conditions.
How similar studies have performed: Other studies utilizing stem cell technology for similar neurodegenerative diseases have shown promise, indicating a potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 30 days or older. * Diagnosis and/or medical history of a condition, disease, genetic background, or trait of interest or healthy control. * Adults with decisional capacity must provide written informed consent unless physical limitations preclude signing. * Adults without decisional capacity to consent must a have diagnosis of Amyotrophic Lateral Sclerosis (ALS), Alzheimer's Disease and Related Dementias (AD/ADRD); Batten Disease, Corticobasal Degeneration (CBD), Dementia, Frontotemporal Dementia (FTD), Huntington Disease, Lewy Body Disease, Multiple Sclerosis, Multiple System Atrophy, Parkinson's Disease (PD), Parkinsonism, and/or Progressive Supranuclear Palsy, and must provide assent; a legally authorized representative (LAR) must also provide written informed consent. * Minors undergoing skin collection for research purposes must have a condition, disease, genetic background, or trait of interest and parental/guardian consent. * Minors undergoing blood, and/or saliva collection for research purposes may have a condition, disease, genetic background, or trait of interest or serve as a healthy control and must have an available parent/guardian to provide consent. * Minors transferring biological samples and associated data from a procedure outside of the research may have a condition, disease, genetic background, or trait of interest or serve as a healthy control and must have an available parent/guardian to provide consent. Exclusion Criteria: * Wards of the state. * For prospective skin samples: history of keloid formation, coagulation disorder, or allergy to the anesthetic. * For prospective blood samples: history of coagulation disorder. * For all prospective sample collections: 1) Subjects who refuse to adhere to NYSCF's and/or a collection site's safety protocol(s) will be excluded; 2) Subjects with an AIDS diagnosis and CD4 count of less than 200 cells per microliter (mcL) of blood will be excluded due to increased risk of infection.
Where this trial is running
New York, New York
- New York Stem Cell Foundation Research Institute — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Laura Andres-Martin, PhD — New York Stem Cell Foundation Research Institute
- Study coordinator: Clinical Research Office
- Email: clinicalresearch@nyscf.org
- Phone: 212-927-1801
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.