Understanding how genes and environment interact in PTSD.
Official title: Modeling gene x environment interactions in post-traumatic stress disorder.
Funded at Icahn School of Medicine at Mount Sinai · NIH-10878745 · Data updated 2026-11-12
This study is looking at how our genes and life experiences work together to affect the risk of developing PTSD, with the goal of helping us understand who might be more vulnerable and improving treatment options for those who need it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 26, 2023 |
| Project end | June 25, 2027 |
| Funding year | 2024 |
| Award (this year) | $51,694 |
| NIH project number | 5F30MH132324-02 |
| Project ID | NIH-10878745 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced traumatic events and may be at risk for PTSD, particularly those with a family history of the disorder.
✕Less likely to help
Patients who have not experienced trauma or do not have a genetic predisposition to PTSD may not benefit from this research.
What this research studies
This research investigates the complex relationship between genetic factors and environmental influences in the development of post-traumatic stress disorder (PTSD). By integrating genetic data from large-scale studies with information about traumatic experiences, the research aims to identify specific genetic variations that may increase susceptibility to PTSD. The approach includes examining how these genetic factors interact with environmental stressors, focusing on brain regions and cell types that may be affected. This could lead to better understanding and identification of individuals at risk for PTSD, ultimately improving treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention and treatment strategies for individuals at risk of developing PTSD.
How similar studies have gone: Previous research has shown promise in understanding gene-environment interactions in various mental health conditions, suggesting that this approach could yield valuable insights for PTSD as well.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Seah, Carina — Icahn School of Medicine at Mount Sinai
- Study coordinator: Seah, Carina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.