Exploring the genetic factors behind post-traumatic stress disorder.
Official title: Understanding the genomic basis of post-traumatic stress disorder through integrative analysis of rare variants and other omics data
Funded at Virginia Commonwealth University · NIH-11139732 · Data updated 2026-11-12
This study is looking at how our genes might influence post-traumatic stress disorder (PTSD) by examining different types of genetic information, and it hopes to find new ways to understand and treat PTSD better for those who experience it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $424,175 |
| NIH project number | 1R21MH137508-01A1 |
| Project ID | NIH-11139732 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with post-traumatic stress disorder, particularly those with a history of traumatic events.
✕Less likely to help
Patients who do not have PTSD or related neuropsychiatric disorders may not receive any benefit from this research.
What this research studies
This research investigates the genetic basis of post-traumatic stress disorder (PTSD) by analyzing both common and rare genetic variants along with other biological data. It aims to integrate information from various omics layers, such as the genome and proteome, to identify pathways and genes associated with PTSD. By leveraging existing large-scale genetic datasets, the study seeks to uncover new insights into the genetic risk factors for PTSD and their relationship with other neuropsychiatric disorders. Patients may benefit from a better understanding of the biological underpinnings of PTSD, which could lead to more targeted treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and personalized care for individuals suffering from PTSD.
How similar studies have gone: Previous research has shown success in identifying genetic factors associated with PTSD, but this study's integrative approach to rare variants is relatively novel.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Nguyen, Tan Hoang — Virginia Commonwealth University
- Study coordinator: Nguyen, Tan Hoang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.