Clinical trial Recruiting at 1 site Interventional Ages 12 to 20

Multi-level school intervention for LGBTQ youth

Official title: Efficacy of a Multi-level School Intervention for LGBTQ Youth

Run by Washington University School of Medicine · NCT05541406 · Data updated 2026-11-12

This study is testing a new program in high schools to see if it helps LGBTQ youth deal with bullying and improve their mental health and school environment.

Quick facts

Study typeInterventional
Ages12 Years to 20 Years
SexAll
Enrollment228 (estimated)
SponsorWashington University School of Medicine
Academic / other
Locations23 sites (El Monte, California and 22 other locations)
StatusRecruiting
StartedSeptember 14, 2022
Main results expectedApril 30, 2027
Study endsApril 30, 2027
Registry record updatedSeptember 11, 2026
Trial IDNCT05541406 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are LGBTQ students enrolled in one of the participating high schools.

Probably not a fit

Patients who do not identify as LGBTQ or are not enrolled in the participating schools may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This intervention aims to test the efficacy of a comprehensive program designed for LGBTQ youth, focusing on their unique experiences of bullying and victimization in schools. The Proud & Empowered (P&E) intervention encourages participants to discuss their challenges and develop coping strategies, while the Make Space initiative seeks to enhance the overall school climate. The study will be conducted across 24 high schools over four years, assessing both individual and school-wide impacts on mental health outcomes and perceptions of school environment. The research will also explore factors influencing the success of the interventions to inform future implementation.

Why it matters

Potential benefit: If successful, this intervention could significantly improve mental health outcomes and school experiences for LGBTQ youth.

How similar studies have gone: Other studies have shown promise in similar interventions aimed at improving the well-being of LGBTQ youth, suggesting a potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* LGBTQ student in one of 24 high schools

Exclusion Criteria:

* Not meeting inclusion criteria

Where it's running

  • Washington University in St. Louis
    St Louis, Missouri, United States
    Recruiting
  • El Monte High School
    El Monte, California, United States
    Completed
  • Arroyo High School
    El Monte, California, United States
    Completed
  • Fernando R Ledesma High School
    El Monte, California, United States
    Completed
  • Mountain View High School
    El Monte, California, United States
    Completed
  • South El Monte High School
    El Monte, California, United States
    Completed
Show 17 more locations
  • Anderson W. Clark Magnet High School
    Glendale, California, United States
    Completed
  • Inglewood High School
    Inglewood, California, United States
    Completed
  • Animo Leadership High School
    Inglewood, California, United States
    Completed
  • Crescenta Valley High School
    La Crescenta-Montrose, California, United States
    Completed
  • Millikan High School
    Long Beach, California, United States
    Completed
  • Animo Pat Brown Charter High School
    Los Angeles, California, United States
    Completed
  • USC Hybrid High School
    Los Angeles, California, United States
    Completed
  • South LA College Prep
    Los Angeles, California, United States
    Completed
  • Larchmont Charter School
    Los Angeles, California, United States
    Completed
  • Brio College Prep
    Los Angeles, California, United States
    Completed
  • Lynwood High School
    Lynwood, California, United States
    Completed
  • Marco Antonio Firebaugh High School
    Lynwood, California, United States
    Completed
  • Vista High School
    Lynwood, California, United States
    Completed
  • Marshall Fundamental Secondary School
    Pasadena, California, United States
    Completed
  • Blair High School
    Pasadena, California, United States
    Completed
  • Pasadena High School
    Pasadena, California, United States
    Completed
  • Rosemead High School
    Rosemead, California, United States
    Completed

Study contacts

  • Principal investigator: Harmony Rhoades, PhD — Washington University School of Medicine
  • Study coordinator: Bethany N Lumsdaine, MPH
  • Email: b.lumsdaine@wustl.edu
  • Phone: 3103826003

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.