Short-term therapy for PTSD symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of a short-term behavioral intervention designed to alleviate symptoms of Post-Traumatic Stress Disorder (PTSD) in adults. The intervention combines imaginal and in-vivo exposure with psychodynamic reprocessing techniques. Participants will undergo a week-long intensive therapy and will be monitored for up to five years to assess recovery patterns and potential relapses. The study will compare outcomes between those receiving the intervention and a waiting list control group, who will eventually have the opportunity to receive treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* • Diagnosis of PTSD with a score of 25 or higher (i.e. severe PTSD) on the Clinician- Administered PTSD Scale (CAPS-5) at screening.

  * Subjects on FDA-approved antidepressants, trazodone, atypical neuroleptic, prazosin, or clonidine may enter the study if they have been on a stable treatment, as determined by the study clinician, for at least 4 weeks prior to randomization. Following randomization, small changes to doses may be allowable at the PI's discretion.
  * Able to provide written informed consent.
  * Able to read and write English/Hebrew.

Exclusion Criteria:

* • Patients with a diagnostic history of bipolar disorder, borderline personality disorder, obsessive-compulsive disorder, schizophrenia or schizoaffective disorder or currently exhibiting psychotic features as determined by the clinical interview; dementia or suspicion thereof, are excluded. Other DSM Axis I disorders are permitted as long as they are not considered primary disorders.

  * Patients with a history of antidepressant-induced hypomania or mania as determined by open-ended psychiatric interview.
  * Current, ongoing serious suicidal risk as assessed by evaluating.
  * Moderate severity or greater Substance Use Disorder (excepting Alcohol Use Disorder) during the 3 months prior to randomization, as determined by the SCID.
  * History of traumatic brain injury (TBI) with loss of consciousness for more than 24 hours or posttraumatic amnesia for more than 7 days may be considered if the trauma occurred more than 1 year ago, and no more than minimal symptoms have persisted over the past year.
  * Any significant history of neurological illness or heart disease.
  * Any signs of major medical or neurological illness on examination or as a result of ECG screening or laboratory studies.
  * Any history indicating learning disability or mental retardation.

Where it's running

• Ben Gurion University of the Negev
  Beersheba, Israel Recruiting

Study contacts

• Study coordinator: Or Duek, Ph.D
• Email: ord@bgu.ac.il
• Phone: +972-507606547

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Non-invasive vagus nerve stimulation (gammaCore) for PTSD

  This study will test whether the handheld gammaCore device, which delivers mild electrical stimulation to the vagus nerve through the neck, can help adults with PTSD reduce their symptoms.

  Recruiting Acacia Clinics · Sunnyvale, California · NCT07523685

• Non‑trauma PTSD treatment for veterans and service members with mild or moderate TBI

  This pilot will test a non‑trauma psychotherapy program to help veterans and service members with mild or moderate traumatic brain injury who have PTSD.

  Recruiting The University of Texas Health Science Center at San Antonio · Fort Hood, Texas · NCT07351305

• Psilocybin-assisted therapy for PTSD after sexual assault

  This trial will test whether a single 25 mg oral dose of psilocybin combined with therapy helps cisgender women who have PTSD from a sexual assault.

  Recruiting Phase 2 Sunstone Medical · Rockville, Maryland · NCT06902974

• Augmented reality-enhanced exposure therapy for PTSD in U.S. military personnel

  This tests whether adding augmented reality to standard exposure therapy helps U.S. military veterans and active-duty adults with PTSD.

  Recruiting Wayne State University · Charleston, South Carolina · NCT06740487

• Working memory training to improve fear extinction in veterans with PTSD

  This study is testing if a special memory training program can help veterans with PTSD learn to manage their fears better.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06629064

• EEG‑guided propofol to induce dreaming as a therapy for PTSD

  This trial will test whether EEG‑guided propofol anesthesia that induces dreaming can reduce symptoms in adults with PTSD.

  Recruiting Phase 2 Stanford University · Stanford, California · NCT06577636

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.