PAP treatment for veterans with PTSD and substance use disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of positive airway pressure (PAP) treatment for obstructive sleep apnea (OSA) in veterans who are undergoing residential treatment for post-traumatic stress disorder (PTSD) and substance use disorder (SUD). It compares the outcomes of veterans receiving PAP therapy to those on a waitlist control group. The study aims to determine if treating OSA can improve overall treatment adherence and outcomes for veterans struggling with these co-occurring conditions. Given the high comorbidity of OSA with PTSD and SUD, this approach seeks to enhance recovery during a critical time in the veterans' treatment journey.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* a Veteran of the U.S. military or Reserve/National Guard member
* have an Apnea Hypopnea Index (AHI) 5 per hour
* experienced trauma that occurred in childhood or adulthood; at least one month post-trauma
* have current DSM-5 diagnoses of substance use disorder (SUD) via Structured Clinical Interview for DSM-Substance Use Disorders (SCID-SUD) module with a minimum 20 days of substance use in the last 90 days (Timeline Follow-back)
* Full post-traumatic stress disorder (PTSD) diagnosis via clinician administered post-traumatic stress disorder (PTSD) scale
* are literate in English
* are on the post-traumatic stress disorder (PTSD) track of the Substance Abuse Residential Rehabilitation Treatment Program (SARRPT) unit
* are capable of giving informed consent

Exclusion Criteria:

* have central sleep apnea (Apnea Hypopnea Index (AHI)\>=5 and \> 50% central apneas)
* arrives on the Substance Abuse Residential Rehabilitation Treatment Program (SARRPT) unit already using a positive airway pressure (PAP) device (Veteran's previously diagnosed with OSA, but not using positive airway pressure (PAP) therapy will be eligible)
* the Substance Abuse Residential Rehabilitation Treatment Program (SARRPT) medical staff advises against the study based on medical history and physical examination; d) history of severe cognitive impairment (via Montreal Cognitive Assessment (MOCA) \< 26)
* history of psychosis or mania independent of substance use will be excluded because the presence of these disorders can impede therapy progress

Where it's running

• VA San Diego Healthcare System, San Diego, CA
  San Diego, California, United States Recruiting

Study contacts

• Principal investigator: Peter Colvonen, PhD — VA San Diego Healthcare System, San Diego, CA
• Study coordinator: Peter Colvonen, PhD
• Email: peter.colvonen@va.gov
• Phone: (858) 552-8585

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.