Home-based exercise program for liver transplant recipients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of different exercise intensities on the rehabilitation of patients who have recently undergone liver transplantation. Participants will be randomly assigned to one of three training groups (low, moderate, or moderate to high intensity) and will engage in a six-month home-based rehabilitation program supervised by a PHOENIX investigator. Assessments of physical fitness, cardiovascular health, liver function, and body composition will occur at baseline, three months, and six months, alongside monthly questionnaires to evaluate well-being and quality of life. The study aims to establish a feasible and effective exercise regimen to improve long-term outcomes for liver transplant recipients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* de novo adult liver transplant recipients with a transplant vintage of two to three months
* access to a home freezer (± -18°C)

Exclusion Criteria:

* Aberrant CPET (abnormal low cardiorespiratory fitness is not considered an exclusion criteria), unstable angina, life-threatening arrhythmias, uncontrolled hypertension/diabetes, HbA1c ≥ 9%, severe pulmonary disease (FEV1 \< 50%), musculoskeletal disorders not allowing physical training on a cycle ergometer, or any other medical reasons by the physician considered to be a contraindication for moderate or high-intensity physical exercise
* multi-organ transplantation (exception: combined liver-kidney transplant is considered eligible for participation)
* ongoing treatment for malignancies
* unable to understand Dutch
* no access to smartphone and/or computer with internet access
* does not willing to except the general conditions of Coachbox. Preparticipation medical screening (cardiopulmonary exercise testing with 12-lead ECG + stratification of cardiovascular risk factors) will be performed by a cardiologist (Dr. Kaatje Goetschalckx at UZ Leuven).

Where it's running

• UZ Leuven
  Leuven, Vlaams-Brabant, Belgium Recruiting

Study contacts

• Study coordinator: Diethard Monbaliu, MD PhD
• Email: diethard.monbaliu@uzleuven.be
• Phone: +3216342361

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.