Early liver transplant for severe alcohol-related liver disease
3/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
This project follows people with severe alcohol-related liver disease who are being considered for liver transplants before six months of sobriety to learn who does best and why.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11161487 on NIH RePORTER |
What this research studies
If I join, researchers will follow people with severe alcohol-associated liver disease who are being evaluated for early liver transplant at centers across the U.S. They will collect medical details, alcohol-use history, treatment information, and psychosocial data over time and track outcomes like survival, liver recovery with abstinence, and transplant results. The team will compare different center practices and alcohol use disorder treatments to refine who should be offered early transplant. Findings will be used to build better risk scores and care guidelines to reduce variation and disparities in access to transplant.
Who could benefit from this research
Good fit: Adults (age 21+) with severe alcohol-associated liver disease who are being considered for liver transplant before six months of abstinence are the ideal candidates.
Not a fit: People without severe alcohol-related liver disease, those who have already recovered without needing a transplant, or those not evaluated at participating centers are unlikely to benefit directly from joining.
Why it matters
Potential benefit: If successful, this work could help more people get the right liver treatment at the right time and reduce unnecessary transplants.
How similar studies have performed: Early liver transplant programs have shown promise in prior single-center studies, but practices vary and this larger multicenter cohort aims to provide stronger, generalizable evidence.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Lucey, Michael Ronan — University of Wisconsin-Madison
- Study coordinator: Lucey, Michael Ronan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.