Condition

Immunosuppression clinical trials and research

• 17Clinical trials
• 114NIH research projects
• 10Countries

Newest Immunosuppression clinical trials

All recruiting trials (17)

• Thymalfasin added to standard care for adults with sepsis and immune dysfunction

  This study tests whether thymosin alpha-1 helps restore immune function in adults with sepsis who have weakened immunity.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07866118

• Metabolic and Functional Study of γδ T Cells in Critically Ill Patients

  Researchers will look at how γδ T cells behave in severely ill patients, including those with sepsis, to see how their metabolism and function change.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Outside of the US · NCT07680816

• Using FibroScan to guide lowering immune-suppressing drugs after liver transplant

  This will test whether using FibroScan to measure liver stiffness lets doctors safely reduce immunosuppressive drugs in adults at least 2 years after a liver transplant who don't have autoimmune liver disease or recent rejection.

  Recruiting University of Alberta · Edmonton, Alberta · NCT07206277

• Preemptive genetic testing to guide tacrolimus treatment for kidney transplant patients

  This study will test whether doing a genetic test before transplant to guide tacrolimus dosing helps people on the kidney transplant waiting list stay safer and use health resources more efficiently.

  Recruiting Phase 4 Instituto de Investigación Hospital Universitario La Paz · Madrid, Madrid · NCT06701825

• Monitoring vaccine responses in immune compromised patients

  This study is trying to see how well vaccines work and how safe they are for people with weakened immune systems.

  Recruiting Pediatric Clinical Research Platform · Geneva · NCT06463119

• Once-daily tacrolimus regimens during the first year after liver transplant

  This will try once-daily tacrolimus with mycophenolate to see if simpler dosing helps people take their medicines and protects the transplanted liver during the first year after a liver transplant.

  Recruiting at 17 sites Phase 4 University Hospital, Limoges · Besançon and 17 other locations · NCT06354179

• Observational study on infections in transplant patients in Germany

  This study looks at how infections affect transplant patients in Germany to see what makes some people more likely to get infections and how it impacts their organ health over time.

  Recruiting Technical University of Munich · München · NCT06346665

• Comparing vaccine responses in kidney transplant patients and their healthy cohabitants

  This study is testing how well the shingles vaccine works in kidney transplant patients on different medications compared to their healthy family members.

  Recruiting Central Adelaide Local Health Network Incorporated · Adelaide, South Australia · NCT06262776

• High-dose Liposomal Amphotericin B for treating disseminated histoplasmosis in AIDS patients

  This study is testing if a single high dose of a medication can safely treat disseminated histoplasmosis in AIDS patients better than the usual lower dose given over two weeks.

  Recruiting at 5 sites Phase 3 Federal University of Health Science of Porto Alegre · Goiânia, Goiás and 4 other locations · NCT05814432

• Understanding blood changes after severe trauma

  This study looks at how severe injuries affect blood and bone marrow in trauma patients to see if it changes their immune response compared to patients having planned hip surgeries.

  Recruiting University of Florida · Gainesville, Florida · NCT05616130

• Comparing two formulations of tacrolimus for liver transplant patients

  This study is testing whether a new extended-release version of tacrolimus causes fewer and less severe tremors in liver transplant patients compared to the standard immediate-release version.

  Recruiting Phase 4 University of British Columbia · Vancouver, British Columbia · NCT05089604

• Combining treatments for children with Crohn's disease

  This study is testing whether combining two treatments for Crohn's disease can help children feel better compared to using just one of the treatments alone.

  Recruiting Phase 4 Children's Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT05043870

• Evaluating endomyocardial biopsy and tailored treatments for inflammatory heart disease

  This study is trying to see if a heart tissue test and personalized treatments can help people with inflammatory heart disease, especially those with myocarditis and heart rhythm issues.

  Recruiting Scientific Institute San Raffaele · Milan, Milano · NCT04521790

• Combining radiofrequency ablation with carrizumab for advanced liver cancer

  This study tests if adding a heat treatment called radiofrequency ablation to a new drug, carrizumab, can help people with advanced liver cancer live longer without their cancer getting worse compared to just using carrizumab alone.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04150744

• Improving hand transplantation for patients with limb loss

  This study is testing if hand transplants can help people who have lost a hand below the elbow to use their new hand better and improve their quality of life.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT02310867

• Observational study of neutropenic patients in Cologne

  This study looks at patients who have low white blood cell counts after chemotherapy for blood cancers to see how it affects their health and what treatments work best for them.

  Recruiting University Hospital of Cologne · Cologne, North Rhine-Westphalia · NCT01821456

• Investigating the link between oral bacteria and immune system issues in gum disease

  This study is trying to see how genetic immune problems affect gum disease and oral health by looking at people with these issues, those with severe gum disease, and healthy volunteers.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01568697

NIH-funded research (newest 40 of 114)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Vascular signals from brain blood vessels influence immune-suppressing cells in glioblastoma

  This grant explores how blood vessel cells in glioblastoma shape immune cells to help the tumor grow, with the aim of making immunotherapies work better for patients.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11583676

• Vascularized niche with local immune protection to transplant insulin-producing cells for Type 1 diabetes

  A new approach aims to transplant insulin-producing cells inside a vascularized pocket with local drug delivery to keep them alive and functioning without full-body immune suppression.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11550529

• AHR-driven immunosuppression in glioblastoma and new therapeutic targets

  A personalized cancer study aims to understand why glioblastoma suppresses the immune system and to find ways to boost anti-tumor immunity in patients with this brain tumor.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11455312

• Fibroblast-made GABA fuels PDAC immune suppression

  In people with pancreatic cancer, this study explores how a specific cell type in the tumor environment uses a brain-like chemical (GABA) to dampen immune attack against the cancer.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11445888

• Biomarker-guided reduction of immunosuppression after liver transplant

  A multicenter trial tests whether using blood biomarkers to guide tapering of immunosuppression in adults with liver transplants can keep people healthy while lowering drug exposure.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11433277

• Understanding and Overcoming T cell Immunosuppression in Glioblastoma (GBM)

  A large research program is looking at how glioblastoma tumors weaken immune responses and how to boost immune cells to fight GBM.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11417398

• Combined targeting of DNA repair and macrophage immunosuppression in BRCA-associated breast cancer

  A study for people with BRCA-related breast cancer exploring a combination treatment that blocks DNA repair and tampers down immune-suppressing cells to help the body's immune response fight the cancer.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11414853

• Personalized immunosuppression for kidney transplant recipients using real-world data and AI

  A kidney transplant grant aims to tailor immunosuppressive therapy to individual patients using real-world health data and artificial intelligence.

  NIH research New York University School of Medicine · New York, United States · NIH-11413765

• Thermal ablation vs LEEP for cervical precancer in women with HIV

  A clinical trial will compare two treatments, thermal ablation and LEEP, for high-grade cervical lesions in women living with HIV or other immunosuppression.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11412602

• Biomarkers to tailor liver transplant immunosuppression

  A multi-center study using blood biomarkers to guide how immunosuppressive drugs are given to liver transplant patients.

  NIH research Northwestern University · Chicago, United States · NIH-11412569

• Role of tissue stiffness in brain tumor immunity

  A study in glioblastoma patients and models aims to understand how the stiffness of the tumor environment affects immune cells and tumor growth.

  NIH research University of Louisville · Louisville, United States · NIH-11399795

• Rewired metabolism and immunosuppression in MYCN-driven neuroblastoma

  A researcher team will study how the MYCN gene changes metabolism and immune responses in high-risk neuroblastoma to find strategies that could help the disease respond to future therapies.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11398164

• Targeting PD-1H (VISTA) to Fight AML Immunosuppression

  A patient-focused look at a new approach that blocks PD-1H (VISTA) to help the immune system fight acute myeloid leukemia.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11394654

• Using blood biomarkers to guide immunosuppression after liver transplant

  This project uses regular blood biomarker checks to help doctors personalize immunosuppression for people who have had a liver transplant to reduce rejection and protect the kidneys.

  NIH research Northwestern University · Chicago, United States · NIH-11392822

• Understanding how DNA methylation affects immune recovery after sepsis

  Researchers are studying how epigenetic changes after sepsis can weaken the immune system and affect long-term health in survivors.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11392537

• Tumor-Selective Bacterial Therapy to Rebuild the Immune Attack on Pancreatic Cancer

  A new bacterial therapy is being tested to target pancreatic cancer, help break down its protective environment, and boost the body’s own immune response.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11391856

• Generating animal-human chimeric livers for transplantation without immunosuppression

  A research grant aims to create human liver tissue inside animals to help patients who need liver transplants without long-term immunosuppressive drugs.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11391135

• RSV vaccine in people with immune suppression: how antibodies form and work

  This grant studies how vaccines for RSV work in people with weakened immune systems and aims to improve how vaccines protect them.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11384417

• Islet transplant coating to protect insulin-producing cells

  A study tests a new coating for transplanted insulin-producing cells to shield them from the immune system and improve survival in Type 1 diabetes.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11382143

• Next-generation vaccine ideas to prevent C. difficile illness

  A new C. difficile vaccine approach is being tested to protect people from serious stomach infections.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11377662

• Excessive lipid metabolism in T cell aging and tumor immunosuppression

  This grant studies why certain T cells become dysfunctional in tumors and how high-fat metabolism contributes to this, with the goal of making immunotherapies work better for cancer patients.

  NIH research Washington University · Saint Louis, United States · NIH-11377564

• Mitochondrial Reprogramming in Tumor-Associated Macrophages to Boost Immunotherapy

  Scientists are studying how changing the energy powerhouses in immune cells inside tumors could help support stronger cancer immunotherapies for patients.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11376428

• Stress-related hormonal signals and immune response in a specific breast cancer type

  A study in triple-negative breast cancer looks at how stress hormones may weaken the body's immune attack and whether blocking those signals could improve cancer treatment.

  NIH research Emory University · Atlanta, United States · NIH-11360686

• Linking cancer driver mutations to how regulatory T cells weaken anti-tumor immunity

  Researchers are studying how common breast cancer mutations may help tumors hide from the immune system and whether this knowledge can lead to new treatments for patients with aggressive breast cancer.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11357784

• Preventing UV-driven skin cancer with a skin-targeted form of R-carvedilol

  A patient-friendly look at a cancer-prevention approach using a skin-targeted version of R-carvedilol to block UV-driven skin cancer without affecting heart health.

  NIH research Western University of Health Sciences · Pomona, United States · NIH-11353903

• Fibroblasts in brain metastases help cancer grow and hide from treatment

  In people with cancer that has spread to the brain, researchers are studying how lung cancer–driven fibroblasts in the brain help cancer cells grow, resist standard therapies, and dampen the immune response.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11345207

• CAR-engineered stem cells to enhance immune suppression in autoimmune diseases

  A Mayo Clinic team is testing engineered mesenchymal stromal cells with CARs to boost their ability to calm immune attacks in autoimmune diseases like GVHD and IBD.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11336895

• Optimizing Immunosuppression and EBV-Seronegative Kidney Allocation to Reduce PTLD Risk

  This grant explores how adjusting immunosuppression and kidney donor matching by EBV status could lower the risk of EBV-related cancers in kidney transplant patients.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11332890

• Stopping immune-suppressing neutrophils to help treat metastatic breast cancer

  Researchers are exploring whether blocking a neutrophil protein called Acod1 can weaken immune-suppressing neutrophils and make immunotherapy work better for people with metastatic breast cancer.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11324967

• Understanding and preventing skin cancers in people who received organ transplants

  This project studies why skin cancers are more common and more aggressive in kidney, liver, or other organ transplant recipients and how to better screen and manage them.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11324610

• How the protein CHI3L1 weakens immune attacks in glioblastoma

  Seeing if blocking CHI3L1 helps the immune system attack glioblastoma in adults with this brain tumor.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11324608

• Immune causes of kidney disease in tuberous sclerosis

  The team is looking at whether immune cells and a protein called B7-H3 help kidney cysts and growths in people with tuberous sclerosis complex.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11324582

• How Brucella enzymes weaken immune defenses

  This research looks at whether enzymes made by Brucella bacteria break down a key molecule in immune cells and help the bacteria cause infections in people.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11324202

• Weakened Listeria bacteria to boost the immune attack against cancer

  This project looks at whether a weakened Listeria bacterium can reprogram tumors so people’s immune systems and immunotherapies can work better against cancer.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11320761

• How IL-6/STAT3 helps CIC-DUX4 sarcoma spread and hide from the immune system

  Researchers will target the IL-6/STAT3 signaling pathway in CIC-DUX4 fusion sarcoma to look for ways to stop cancer spread in children and young adults.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11311805

• How weakened immune systems affect long-lasting COVID-19 infections and viral changes

  Researchers are learning how COVID-19 can persist and change in people with weakened immune systems, especially those with blood cancers.

  NIH research New York University School of Medicine · New York, United States · NIH-11308774

• How some p53 gene changes help head and neck cancers spread and hide from the immune system

  Researchers are looking at whether blocking a protein called MCM5 can stop p53‑mutant head and neck cancers from becoming unstable, spreading, and weakening the immune system.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11300228

• How the immune protein IDO weakens defenses in tuberculosis and whether blocking it helps

  This work looks at whether blocking a protein called IDO can help the immune system fight tuberculosis in people and in animal models, including TB/HIV co-infection.

  NIH research Texas Biomedical Research Institute · San Antonio, United States · NIH-11295984

• Investigating how stress affects the immune response in aggressive breast cancer.

  This study is looking at how stress affects the immune system's ability to fight triple negative breast cancer and hopes to find ways, like using certain medications, to make treatments work better for patients dealing with this type of cancer.

  NIH research Emory University · Atlanta, United States · NIH-11287201

• Helping CAR T cells fight solid tumors better

  Researchers are developing ways to protect engineered CAR T cells so they survive and kill cancer cells inside solid tumors.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11262841

Related topics

Quick answers

How many Immunosuppression clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in China (4 trials), United States (3 trials), Germany (2 trials), Canada (2 trials), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →