Early liver transplant for severe alcoholic hepatitis
Multidisciplinary approach to study of patients with Severe Alcoholic Hepatitis Undergoing Liver Transplantation
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11101244
This work looks at using earlier liver transplants to save people with life-threatening severe alcoholic hepatitis who do not get better with medical treatment.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11101244 on ClinicalTrials.gov |
What this research studies
From a patient's view, the team collects information on people with severe alcoholic hepatitis who are too sick to wait the usual 6-month sobriety period and may receive an early liver transplant. They follow clinical outcomes such as survival, return to alcohol use, and quality of life after transplant and compare these to more typical transplant recipients. The program pools the largest cohort of such patients through the DELTA Center at Johns Hopkins and uses standardized psychosocial evaluations and follow-up procedures. The aim is to refine who should be eligible for early transplant and to track long-term outcomes.
Who could benefit from this research
Good fit: Ideal candidates are people with severe alcoholic hepatitis who are not responding to medical treatment and face very high short-term risk of death, and who are being considered for early liver transplant.
Not a fit: People with mild alcohol-related liver disease, those who can safely wait the usual time before transplant, or those who are not transplant candidates are unlikely to benefit from this program.
Why it matters
Potential benefit: If successful, this could increase access to lifesaving transplants for patients dying from severe alcoholic hepatitis and help create fair, evidence-based listing rules.
How similar studies have performed: Johns Hopkins' pilot experience and other small series have shown excellent one-year survival and similar relapse rates after early transplant, but larger and longer-term data and national consensus remain limited.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAMERON, ANDREW M. — JOHNS HOPKINS UNIVERSITY
- Study coordinator: CAMERON, ANDREW M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.