Improving liver transplantation outcomes using advanced preservation techniques
Molecular Targets of Preservation Injury Mitigated by Hypothermic Oxygenated Machine Perfusion in Liver Transplantation
This study is looking at a new way to keep liver donations healthy longer, especially from older donors or those with fatty livers, to help patients who need liver transplants recover better and have fewer problems after surgery.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11123341 on NIH RePORTER |
What this research studies
This research investigates how a new method called Hypothermic Oxygenated Machine Perfusion (HMP-O2) can enhance the preservation of liver grafts from extended criteria donors, such as older individuals or those with fatty livers. By continuously flushing the liver with an oxygenated solution, this technique aims to reduce damage during preservation and improve outcomes after transplantation. The study will explore the molecular pathways affected by this method to better understand its benefits. Patients receiving liver transplants may experience fewer complications and better recovery due to this innovative approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals requiring liver transplantation, particularly those who may receive grafts from older or higher-risk donors.
Not a fit: Patients who are not candidates for liver transplantation or those receiving grafts from standard criteria donors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved liver transplant outcomes and increased availability of donor organs for patients in need.
How similar studies have performed: Early clinical trials in the US and Europe have shown promising results for similar preservation techniques, indicating potential for success in this research.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Lunsford, Keri Elizabeth — Rutgers Biomedical and Health Sciences
- Study coordinator: Lunsford, Keri Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.