Using Quantra bedside clot testing to guide blood transfusions during liver transplant
Assessment of a Quantra-guided Transfusion Algorithm in Liver Transplantation
This will test whether using Quantra bedside clot testing during liver transplants can reduce bleeding and the need for blood transfusions in adults with end-stage liver disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 56 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Toulouse Academic / other |
| Locations | 1 site (Toulouse) |
| Trial ID | NCT06749405 on ClinicalTrials.gov |
What this trial studies
This interventional study compares a transfusion algorithm guided by the Quantra bedside viscoelastic sonorheometry device with a conventional transfusion approach in adults undergoing orthotopic liver transplantation. Participants receive intraoperative haemostatic management according to one of the two predefined algorithms, and transfusion volumes and bleeding-related outcomes are recorded. The trial focuses on real-time guidance of blood-product administration during the perioperative period to respond to dynamic coagulation changes common in end-stage liver disease. Primary outcomes include transfusion requirements and measures of intraoperative bleeding, with safety monitored throughout.
Who should consider this trial
Good fit: Adults aged 18 or older with end-stage liver disease scheduled for liver transplantation who can provide informed consent and are not listed for multi-organ transplant are ideal candidates.
Not a fit: Patients undergoing multi-organ transplantation, those with congenital bleeding disorders, pregnant or breastfeeding women, or people under legal protection are excluded and unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the Quantra-guided approach could reduce blood transfusions and bleeding during liver transplantation, potentially lowering complications and resource use.
How similar studies have performed: Viscoelastic-guided transfusion strategies using TEG or ROTEM have shown benefit in some surgical settings, but Quantra's sonorheometric approach is newer and less extensively validated in liver transplantation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years or older * Patient with ESLD undergoing liver transplantation * Individuals affiliated with or beneficiaries of a social security scheme * Free and informed written consent obtained in writing from the patient, or where applicable from the trusted person/family member/close relative Non-inclusion Criteria: * Multi-organ transplantation * Congenital haemostasis disorder (such as haemophilia) * Patient under juridical protection (persons deprived of liberty or under curatorship or guardianship or safeguard of justice) * Pregnant or breast-feeding woman * Patient already enrolled in another interventional study with primary or secondary objective of reducing perioperative bleeding or transfusion
Where this trial is running
Toulouse
- Toulouse University Hospital — Toulouse, France (Recruiting)
Study contacts
- Principal investigator: Guillaume PORTA BONETE, Md — University Hospital, Toulouse
- Study coordinator: Guillaume PORTA BONETE, Md
- Email: porta-bonete.g@chu-toulouse.fr
- Phone: 561323565
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.