INTEGRATE: Improving Biopsychosocial Care for Early Liver Transplant in Alcohol-Related Liver Disease
Official title: 2/4-The INTEGRATE Study: Evaluating INTEGRATEd care to Improve Biopsychosocial Outcomes of Early Liver Transplantation for Alcohol-Associated Liver Disease
Funded at Columbia University Health Sciences · NIH-11402223 · Data updated 2026-11-12
A multi-center study aims to improve how early liver transplant decisions are made for people with alcohol-related liver disease by focusing on medical, behavioral, and social factors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $434,417 |
| NIH project number | 5R01AA030958-04 |
| Project ID | NIH-11402223 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with alcohol-associated liver disease who are being evaluated for liver transplant and have varying levels of alcohol abstinence and biopsychosocial factors.
✕Less likely to help
Patients without access to transplant centers or those not pursuing transplant may experience limited direct benefit.
What this research studies
This project looks at who gets referred for early liver transplant, how biopsychosocial factors affect outcomes, and how integrated care for alcohol use and liver disease can support abstinence and survival. It will use prospective data from multiple centers to build risk models that include biopsychosocial measures. The goal is to guide better referral, standardized assessments, and partnerships between liver teams and addiction care to improve patient outcomes after transplant.
Why it matters
Potential benefit: If successful, patients could receive more timely, personalized transplant decisions supported by integrated addiction and medical care.
How similar studies have gone: Prior retrospective data suggested acceptable outcomes with early transplant for alcohol-associated liver disease, but prospective, multicenter validation is needed.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Verna, Elizabeth Clarice — Columbia University Health Sciences
- Study coordinator: Verna, Elizabeth Clarice
Related research
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-
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-
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HOPE liver transplant: reducing infections and cancer risk for HIV-positive recipients
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-
Early liver transplant decisions for severe alcohol-related liver disease
A large study follows adults with severe alcohol-related liver disease to understand how to best select and manage patients for early liver transplantation.
-
Early Liver Transplant for Severe Alcoholic Hepatitis
A hospital-based program is studying whether offering an early liver transplant to patients with severe alcoholic hepatitis can save lives when standard medical treatment fails.
-
Early liver transplant for severe alcoholic hepatitis (SAH) to save lives
A Johns Hopkins program is testing whether giving an early liver transplant to patients with severe alcoholic hepatitis who can’t be helped by standard treatments can save lives and reduce relapse risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.