Early liver transplant decisions for severe alcohol-related liver disease
Official title: 1/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
Funded at University of Southern California · NIH-11418080 · Data updated 2026-11-12
A large study follows adults with severe alcohol-related liver disease to understand how to best select and manage patients for early liver transplantation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $577,500 |
| NIH project number | 5R01AA030960-04 |
| Project ID | NIH-11418080 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 and older with severe alcohol-related liver disease considered for early liver transplantation.
✕Less likely to help
Patients not experiencing or at risk for advanced liver disease or not considered for transplantation may not directly benefit.
What this research studies
This project tracks patients with alcohol-related liver disease over time as they may be evaluated for early liver transplantation. It gathers data from multiple recruitment sites to identify which criteria and treatments lead to better outcomes. The goal is to improve access, timing, and stewardship of liver transplants for people with alcohol-related liver conditions. I’d learn how different approaches to sobriety treatment and pre- and post-transplant care impact survival and quality of life.
Why it matters
Potential benefit: If successful, the study could lead to clearer guidelines that help eligible patients receive timely, appropriate liver transplantation.
How similar studies have gone: Prior work shows variability in ELT practices and potential to improve outcomes with better selection criteria.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Terrault, Norah a. — University of Southern California
- Study coordinator: Terrault, Norah a.
Related research
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Early liver transplant for severe alcoholic hepatitis (SAH) to save lives
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-
ACCELERATE-PACE: Early Liver Transplantation for Alcohol-Related Liver Disease
A large study follows adults with severe alcohol-related liver disease to understand who can benefit from early liver transplantation and how best to manage care.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.