Early liver transplant options for severe alcohol-related liver disease
2/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
This project follows adults with severe alcohol-related liver disease who are being considered for early liver transplant to find which selection and care approaches help patients do best.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11141790 on NIH RePORTER |
What this research studies
If you have severe alcohol-related liver disease and are being considered for an early liver transplant (before six months of sobriety), this project will follow you over time across multiple transplant centers. Researchers will collect medical, psychosocial, and treatment information, track outcomes like liver recovery with abstinence and post-transplant success, and study how alcohol use disorder treatments work in this group. The consortium pools data from many regions to compare different selection practices, refine risk scores, and identify best care practices to reduce disparities.
Who could benefit from this research
Good fit: Adults (age 21+) with severe alcohol-associated liver disease who are being evaluated for or referred for early liver transplantation are the ideal candidates.
Not a fit: People without alcohol-associated liver disease, children and teens, or patients not under consideration for transplant are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could make transplant decisions fairer and safer by identifying who truly benefits from early liver transplant and improving care before and after transplant.
How similar studies have performed: Previous single-center and smaller studies have shown promising results for carefully selected early transplants, but large multicenter cohort data like this are limited.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Serper, Marina — University of Pennsylvania
- Study coordinator: Serper, Marina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.