Modeling liver blood flow during surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop and validate a mathematical model to predict the evolution of the portocaval gradient during liver surgeries, including partial hepatectomy and liver transplantation. By utilizing hemodynamic modeling, the research seeks to enhance the selection of candidates for liver surgery and anticipate the risk of postoperative liver failure. The approach focuses on three surgical scenarios of increasing complexity, addressing the challenges posed by chronic liver diseases and the need for precise surgical evaluations. The ultimate goal is to improve patient outcomes by minimizing the risks associated with liver surgeries.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Liver pathology requiring minor or major hepatectomy by laparotomy, or transplantation with small livers (graft weight/patient weight ratio \< 0. 01) or partial livers (living donor recipient or auxiliary grafts) or portal embolization (all patients scheduled for major hepatectomy on cirrhosis, or expanded hepatectomy on non-cirrhotic liver if and only if the ratio of future remaining liver/body weight is \<0.5.
* Membership in a social security plan
* Written consent to participate in this research
* Adult patients (age ≥18 years)

Exclusion Criteria:

* Pregnant or breastfeeding women
* Patient under guardianship or curatorship
* Refusal to participate in the study
* Contraindication to performing of MRI.
* Patient Under State medical aid

Where it's running

• Centre Hépato-Biliaire - Hôpital Paul Brousse
  Villejuif, Val de Marne, France Recruiting

Study contacts

• Study coordinator: GOLSE Nicolas, M.D
• Email: nicolas.golse@aphp.fr
• Phone: 06 71 28 24 03

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Everolimus-based calcineurin-free immunosuppression one year after liver transplant

  This trial tests whether switching to or using everolimus with reduced calcineurin inhibitors after year one post-liver transplant can protect kidney function while maintaining graft health in adults at low rejection risk.

  Recruiting Phase 3 Hannover Medical School · Heidelberg, Baden-Wurttemberg and 15 other locations · NCT07739914

• Normothermic machine perfusion to re-evaluate declined donor livers and shorten transplant waiting time

  This trial tests whether keeping declined donor livers functioning on a normothermic perfusion machine can make more livers usable and help adults on the transplant waiting list (ReMELD‑Na ≤21) get transplanted sooner.

  Recruiting at 10 sites Charite University, Berlin, Germany · Hamburg, Free and Hanseatic City of Hamburg and 9 other locations · NCT06874296

• Sleep quality and its determinants during the liver transplant pathway

  This study tests how sleep quality changes from before liver transplantation to six months after, in adults on the transplant waitlist at a single hospital.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07674355

• Preoperative CIMT and Intraoperative Hemodynamics in Liver Transplant

  This study looks at whether a higher carotid IMT measured before surgery is linked to more unstable blood pressure during liver transplant.

  Recruiting Dicle University · Diyarbakır · NCT07660679

• Metastatic liver cancer patient registry from multiple Chinese centers

  This is a registry that collects real-world data on adults with liver metastases to understand patterns and prognosis and to support future research.

  Recruiting at 2 sites Anhui Provincial Hospital · Bengbu, Anhui and 2 other locations · NCT07602504

• Reference framework for outcomes after machine-preserved liver transplantation in Europe

  This study tests how liver transplants that use machine perfusion perform in real-world practice, to see how different perfusion methods relate to outcomes for adults in Europe.

  Recruiting at 4 sites University Medical Center Groningen · Innsbruck and 37 other locations · NCT07585890

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.