Comparing hemodynamic monitoring techniques during liver transplantation
"Monitoraggio Emodinamico Intraoperatorio in OLT"
NA · IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT06703008
This study is testing two different ways to monitor blood flow during liver transplant surgery to see if one method can help reduce low blood pressure during the operation.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 180 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna (other) |
| Locations | 1 site (Bologna, Emilia-Romagna) |
| Trial ID | NCT06703008 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to compare two hemodynamic monitoring techniques during orthotopic liver transplantation (OLT) to determine if one method can reduce intraoperative hypotension time. Participants will be randomized to receive either conventional monitoring with a pulmonary artery catheter or monitoring with transesophageal echocardiography (TEE). The study will evaluate differences in intraoperative hypotension duration and secondary outcomes such as organ dysfunction and mortality. Given the complexities of OLT, effective hemodynamic management is crucial for improving patient outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals who are candidates for liver transplantation and can provide informed consent.
Not a fit: Patients with bleeding esophageal varices, bleeding gastro-esophageal ulcers, or gastro-esophageal anomalies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved hemodynamic management during liver transplantation, potentially reducing complications and mortality.
How similar studies have performed: While the use of TEE in liver transplantation has increased, this study is among the first randomized controlled trials to evaluate its effectiveness compared to traditional methods.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Candidate for Liver Transplantation * Acceptance of informed consent to participate in the study. Exclusion Criteria: * Bleeding esophageal varices * Bleeding gastro-esophageal ulcer * Gastro-esophageal anomalies (congenital, acquired or post-surgical)
Where this trial is running
Bologna, Emilia-Romagna
- IRCSS AOU di Bologna — Bologna, Emilia-Romagna, Italy (RECRUITING)
Study contacts
- Principal investigator: Amedeo Bianchini, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Study coordinator: Amedeo Bianchini, MD
- Email: amedeo.bianchini@aosp.bo.it
- Phone: 051 2143101
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Liver Transplantation, Hemodynamic Monitoring, TEE, Transesophageal Echocardiography, Transoesophageal Echocardiography