Evaluating early liver transplantation for patients with severe alcohol-related liver disease
3/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
This study is looking at how early liver transplants can help people with serious liver problems caused by alcohol, and it aims to find the best ways to choose patients who might benefit from a transplant, especially focusing on how staying sober can improve liver health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10909188 on NIH RePORTER |
What this research studies
This research investigates the outcomes of early liver transplantation (ELT) for patients suffering from severe alcohol-associated liver disease (ALD). It involves a longitudinal cohort of patients who are evaluated for ELT, aiming to refine selection criteria and management practices across multiple recruitment sites in the U.S. The study seeks to understand the impact of alcohol abstinence on liver health and the potential for liver recovery, which could influence the need for transplantation. By analyzing patient data, the research aims to establish best practices for identifying candidates who may benefit from ELT.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old with severe alcohol-associated liver disease who are being considered for early liver transplantation.
Not a fit: Patients with liver disease not associated with alcohol or those who do not meet the criteria for early liver transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve access to liver transplantation for patients with severe alcohol-related liver disease, potentially saving lives.
How similar studies have performed: Previous research has shown variability in practices regarding early liver transplantation, indicating that this approach could lead to significant advancements in treatment protocols.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Lucey, Michael Ronan — University of Wisconsin-Madison
- Study coordinator: Lucey, Michael Ronan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.