Evaluating early liver transplantation for patients with severe alcohol-related liver disease
Official title: 3/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
Funded at University of Wisconsin-Madison · NIH-10909188 · Data updated 2026-11-12
This study is looking at how early liver transplants can help people with serious liver problems caused by alcohol, and it aims to find the best ways to choose patients who might benefit from a transplant, especially focusing on how staying sober can improve liver health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 17, 2023 |
| Project end | July 31, 2030 |
| Funding year | 2024 |
| Award (this year) | $388,724 |
| NIH project number | 5R01AA030966-02 |
| Project ID | NIH-10909188 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old with severe alcohol-associated liver disease who are being considered for early liver transplantation.
✕Less likely to help
Patients with liver disease not associated with alcohol or those who do not meet the criteria for early liver transplantation may not benefit from this research.
What this research studies
This research investigates the outcomes of early liver transplantation (ELT) for patients suffering from severe alcohol-associated liver disease (ALD). It involves a longitudinal cohort of patients who are evaluated for ELT, aiming to refine selection criteria and management practices across multiple recruitment sites in the U.S. The study seeks to understand the impact of alcohol abstinence on liver health and the potential for liver recovery, which could influence the need for transplantation. By analyzing patient data, the research aims to establish best practices for identifying candidates who may benefit from ELT.
Why it matters
Potential benefit: If successful, this research could improve access to liver transplantation for patients with severe alcohol-related liver disease, potentially saving lives.
How similar studies have gone: Previous research has shown variability in practices regarding early liver transplantation, indicating that this approach could lead to significant advancements in treatment protocols.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Lucey, Michael Ronan — University of Wisconsin-Madison
- Study coordinator: Lucey, Michael Ronan
Related research
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Early liver transplant decisions for severe alcohol-related liver disease
A large study follows adults with severe alcohol-related liver disease to understand how to best select and manage patients for early liver transplantation.
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Early Liver Transplant for Severe Alcoholic Hepatitis
A hospital-based program is studying whether offering an early liver transplant to patients with severe alcoholic hepatitis can save lives when standard medical treatment fails.
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Early liver transplant for severe alcoholic hepatitis (SAH) to save lives
A Johns Hopkins program is testing whether giving an early liver transplant to patients with severe alcoholic hepatitis who can’t be helped by standard treatments can save lives and reduce relapse risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.