Integrated care to improve outcomes after early liver transplant for alcohol-related liver disease
Official title: 3/4-The INTEGRATE Study: Evaluating INTEGRATEd Care to Improve Biopsychosocial Outcomes of Early Liver Transplantation for Alcohol-Associated Liver Disease
Funded at University of Miami School of Medicine · NIH-11402257 · Data updated 2026-11-12
A multi-center study tests how coordinated medical and psychosocial care around early liver transplant for people with alcohol-related liver disease can improve their health and recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | August 10, 2023 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $400,730 |
| NIH project number | 5R01AA030968-04 |
| Project ID | NIH-11402257 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with advanced alcohol-related liver disease considering or receiving early liver transplant.
✕Less likely to help
Patients not pursuing early liver transplant or not engaging in integrated care may see fewer benefits.
What this research studies
This project brings together clinics from several universities to study early liver transplant for ALD, focusing on biopsychosocial factors, referral patterns, and how integrated care affects outcomes after transplant. Researchers will collect standardized measurements, develop risk models for patient-centered outcomes, and evaluate how combined medical and behavioral support influences abstinence and survival. Participants would be adults with advanced ALD considering or undergoing early liver transplant, and care teams will implement structured, integrated support. The study aims to generate practical knowledge that could guide future care pathways and improve post-transplant results.
Why it matters
Potential benefit: If successful, patients with alcohol-related liver disease could receive more coordinated care that improves abstinence, transplant success, and long-term health.
How similar studies have gone: Previous studies suggest integrated care improves abstinence and outcomes, but prospective multi-center data are needed; this study seeks to build on that with broader, standardized data.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Goldberg, David Seth — University of Miami School of Medicine
- Study coordinator: Goldberg, David Seth
Related research
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-
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HOPE liver transplant: reducing infections and cancer risk for HIV-positive recipients
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Early liver transplant decisions for severe alcohol-related liver disease
A large study follows adults with severe alcohol-related liver disease to understand how to best select and manage patients for early liver transplantation.
-
Early Liver Transplant for Severe Alcoholic Hepatitis
A hospital-based program is studying whether offering an early liver transplant to patients with severe alcoholic hepatitis can save lives when standard medical treatment fails.
-
Early liver transplant for severe alcoholic hepatitis (SAH) to save lives
A Johns Hopkins program is testing whether giving an early liver transplant to patients with severe alcoholic hepatitis who can’t be helped by standard treatments can save lives and reduce relapse risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.