Integrated care to improve outcomes after early liver transplant for alcohol-related liver disease
1/4-The INTEGRATE Study: Evaluating INTEGRATEd Care to Improve Biopsychosocial Outcomes of Early Liver Transplantation for Alcohol-Associated Liver Disease
Looking at whether coordinated liver and addiction care helps people with alcohol-related liver disease who receive early liver transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11144380 on NIH RePORTER |
What this research studies
If you have alcohol-related liver disease and are being considered for an early liver transplant, this project follows you at several transplant centers to collect medical, behavioral, and social information. The team will document who gets referred for early transplant, use validated questionnaires and clinical tests to measure biopsychosocial factors, and build models that predict outcomes after transplant. They will compare results for patients who receive integrated addiction and liver care versus usual care across multiple centers. Patients and transplant teams help choose which measures matter and how follow-up is done.
Who could benefit from this research
Good fit: Adults with alcohol-associated liver disease who are being evaluated for or have received an early liver transplant (generally with less than six months of alcohol abstinence) are the ideal candidates.
Not a fit: People without alcohol-related liver disease, those not undergoing transplant evaluation, or patients who are unwilling or unable to engage in integrated addiction care are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this work could decrease relapse and improve survival and quality of life by standardizing integrated addiction and transplant care for people receiving early liver transplants.
How similar studies have performed: Retrospective studies of early liver transplant for severe alcohol-associated hepatitis have shown acceptable outcomes, but prospective multicenter work including biopsychosocial measures is novel and less tested.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Vanwagner, Lisa B — Ut Southwestern Medical Center
- Study coordinator: Vanwagner, Lisa B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.