Evaluating early liver transplantation for patients with severe alcohol-related liver disease
2/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
This study is looking at how early liver transplants can help people with serious liver problems caused by alcohol, and it aims to find the best ways to choose patients for these transplants and support their recovery, so they can get the care they need.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10909244 on NIH RePORTER |
What this research studies
This research investigates the outcomes of early liver transplantation (ELT) for patients suffering from severe alcohol-associated liver disease (ALD). It involves a longitudinal cohort of patients who are evaluated for ELT, aiming to refine selection criteria and management practices across various medical centers. The study seeks to understand the impact of alcohol abstinence on liver health and the potential for liver recovery, which could influence the need for transplantation. By gathering data from multiple recruitment sites, the research aims to establish best practices and improve access to care for patients in need.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who are experiencing severe alcohol-associated liver disease and are being considered for early liver transplantation.
Not a fit: Patients with liver disease not related to alcohol or those who do not meet the criteria for early liver transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved criteria for liver transplantation, potentially saving lives and enhancing recovery for patients with severe alcohol-related liver disease.
How similar studies have performed: Previous research has shown variability in practices regarding early liver transplantation, indicating that this approach could lead to significant advancements in treatment protocols.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Serper, Marina — University of Pennsylvania
- Study coordinator: Serper, Marina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.