Evaluating eye characteristics to improve liver transplant outcomes
Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters
This study is testing whether eye features can help doctors better understand and improve health outcomes for people with chronic liver disease before and after they get a liver transplant.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Zhongshan Ophthalmic Center, Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT06756009 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between ocular biological characteristics and the overall health of patients with chronic liver disease before and after liver transplantation. It aims to develop a clinical prediction model that incorporates ocular biometric features to enhance disease management. The study utilizes a bidirectional cohort approach, analyzing retrospective data while also prospectively collecting patient information to refine and validate the model. Participants will undergo ophthalmic examinations alongside general health assessments.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with late-stage liver disease or varying degrees of cirrhosis awaiting liver transplantation.
Not a fit: Patients with a history of other organ transplants, significant eye diseases, or major systemic conditions unrelated to liver disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostic models for liver transplantation, enhancing patient outcomes.
How similar studies have performed: While the approach of integrating ocular parameters into liver transplant prognosis is innovative, similar studies have shown promise in other areas of medicine, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age greater than or equal to 18 years old; 2. Late stage liver disease patients waiting for liver transplantation treatment, as well as patients with varying degrees of cirrhosis; 3. Can collect complete basic demographic information, liver function blood test indicators, liver pathology and imaging examination results; 4. Can cooperate with eye OCT, OCTA and other examinations, and obtain qualified examination parameters; 5. Voluntarily follow the clinical trial protocol and sign the informed consent form. Exclusion Criteria: 1. History of other organ transplant surgeries; 2. History of intraocular laser treatment, medication injection, and surgery; 3. History of high myopia, glaucoma, and retinal choroidal related eye diseases; 4. History of major systemic diseases other than liver disease; 5. Individuals whose overall body and eye conditions cannot cooperate with eye examinations.
Where this trial is running
Guangzhou, Guangdong
- Zhongshan Ophthalmic Center, Sun Yat-sen University — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Study coordinator: Zizheng Cao, M.D.
- Email: caozzh@mail2.sysu.edu.cn
- Phone: +86-13201672078
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.