Evaluating eye characteristics to improve liver transplant outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between ocular biological characteristics and the overall health of patients with chronic liver disease before and after liver transplantation. It aims to develop a clinical prediction model that incorporates ocular biometric features to enhance disease management. The study utilizes a bidirectional cohort approach, analyzing retrospective data while also prospectively collecting patient information to refine and validate the model. Participants will undergo ophthalmic examinations alongside general health assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age greater than or equal to 18 years old;
2. Late stage liver disease patients waiting for liver transplantation treatment, as well as patients with varying degrees of cirrhosis;
3. Can collect complete basic demographic information, liver function blood test indicators, liver pathology and imaging examination results;
4. Can cooperate with eye OCT, OCTA and other examinations, and obtain qualified examination parameters;
5. Voluntarily follow the clinical trial protocol and sign the informed consent form.

Exclusion Criteria:

1. History of other organ transplant surgeries;
2. History of intraocular laser treatment, medication injection, and surgery;
3. History of high myopia, glaucoma, and retinal choroidal related eye diseases;
4. History of major systemic diseases other than liver disease;
5. Individuals whose overall body and eye conditions cannot cooperate with eye examinations.

Where it's running

• Zhongshan Ophthalmic Center, Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Zizheng Cao, M.D.
• Email: caozzh@mail2.sysu.edu.cn
• Phone: +86-13201672078

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.