Evaluating early liver transplantation for patients with severe alcohol-related liver disease
1/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
This study is looking at how early liver transplants can help people with severe liver problems caused by alcohol, and it aims to find the best ways to choose patients for the transplant and support their recovery, especially focusing on how quitting alcohol can improve their liver health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10895509 on NIH RePORTER |
What this research studies
This research investigates the outcomes of early liver transplantation (ELT) for patients suffering from severe alcohol-associated liver disease (ALD). It involves a longitudinal cohort of patients who are evaluated for ELT, aiming to refine selection criteria and management practices across various medical centers. The study seeks to understand the impact of alcohol abstinence on liver health and the potential for liver recovery, which could influence the need for transplantation. By analyzing data from multiple recruitment sites, the research aims to establish best practices for treating patients with ALD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old with severe alcohol-associated liver disease who are being considered for early liver transplantation.
Not a fit: Patients with liver disease not related to alcohol consumption or those who do not meet the criteria for early liver transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved access to liver transplantation for patients with severe alcohol-related liver disease, potentially saving lives.
How similar studies have performed: Previous research has shown variability in practices regarding early liver transplantation, indicating that this approach could lead to significant advancements in treatment protocols.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Terrault, Norah a. — University of Southern California
- Study coordinator: Terrault, Norah a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.