Evaluating early liver transplantation for patients with severe alcohol-related liver disease
Official title: 1/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
Funded at University of Southern California · NIH-10895509 · Data updated 2026-11-12
This study is looking at how early liver transplants can help people with severe liver problems caused by alcohol, and it aims to find the best ways to choose patients for the transplant and support their recovery, especially focusing on how quitting alcohol can improve their liver health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | July 31, 2030 |
| Funding year | 2024 |
| Award (this year) | $577,406 |
| NIH project number | 5R01AA030960-02 |
| Project ID | NIH-10895509 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old with severe alcohol-associated liver disease who are being considered for early liver transplantation.
✕Less likely to help
Patients with liver disease not related to alcohol consumption or those who do not meet the criteria for early liver transplantation may not benefit from this research.
What this research studies
This research investigates the outcomes of early liver transplantation (ELT) for patients suffering from severe alcohol-associated liver disease (ALD). It involves a longitudinal cohort of patients who are evaluated for ELT, aiming to refine selection criteria and management practices across various medical centers. The study seeks to understand the impact of alcohol abstinence on liver health and the potential for liver recovery, which could influence the need for transplantation. By analyzing data from multiple recruitment sites, the research aims to establish best practices for treating patients with ALD.
Why it matters
Potential benefit: If successful, this research could lead to improved access to liver transplantation for patients with severe alcohol-related liver disease, potentially saving lives.
How similar studies have gone: Previous research has shown variability in practices regarding early liver transplantation, indicating that this approach could lead to significant advancements in treatment protocols.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Terrault, Norah a. — University of Southern California
- Study coordinator: Terrault, Norah a.
Related research
Other NIH-funded projects on the same topics.
-
Targeting a specific CD38 form to protect livers from injury after transplant
A new approach tests a selective drug to protect donor livers from injury during transplant, potentially increasing usable organs and improving transplant outcomes.
-
Regulatory dendritic cell therapy to reduce immunosuppressive drugs after liver transplant
A new approach using donor-derived regulatory dendritic cells is being tested to help adults who receive a liver transplant live without relying on traditional immunosuppressive drugs.
-
HOPE liver transplant: reducing infections and cancer risk for HIV-positive recipients
This grant aims to better understand why HIV-positive liver transplant recipients face higher infection and cancer risks and to improve safety and outcomes for these patients.
-
Early liver transplant decisions for severe alcohol-related liver disease
A large study follows adults with severe alcohol-related liver disease to understand how to best select and manage patients for early liver transplantation.
-
Early Liver Transplant for Severe Alcoholic Hepatitis
A hospital-based program is studying whether offering an early liver transplant to patients with severe alcoholic hepatitis can save lives when standard medical treatment fails.
-
Early liver transplant for severe alcoholic hepatitis (SAH) to save lives
A Johns Hopkins program is testing whether giving an early liver transplant to patients with severe alcoholic hepatitis who can’t be helped by standard treatments can save lives and reduce relapse risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.