Sponsor or institution
Clinical trials and research at IRCCS San Raffaele
As of November 12, 2026, Find a Trial lists 110 clinical trials run by IRCCS San Raffaele that are recruiting, at sites in 11 countries (most in Italy (110), France (2), Turkey (Türkiye) (2)). 2 were first registered in the last 30 days. By phase: Phase 2 (6). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 110Clinical trials
- 2New in 30 days
- 11Countries
Newest trials
All recruiting trials (110)
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Effective Communication in VBAC Counseling
This study tests how clearly doctors and midwives explain VBAC options during prenatal visits and whether patients feel understood.
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CAR-T Therapy Safety, Response, and Immune-Escape: Observational Study in Adults
This observational study looks at adults who receive CAR-T cell therapy or bispecific antibodies to see which factors predict response and immune-related side effects.
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Photon-counting CT versus traditional CT for suspected coronary artery disease
This trial tests whether photon-counting CT can better diagnose obstructive CAD in people who need a coronary CTA than the standard energy-integrating detector CT.
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Intensive 4-week postoperative multimodal rehab after proximal pancreatic surgery
This study tests whether a 4-week multimodal rehabilitation program can help adults who have severe complications after proximal pancreatic surgery recover better.
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Engineered HMGB1 protein as a companion therapy for LAMA2-related muscular dystrophy
This study tests how existing patient samples from people with LAMA2-related muscular dystrophy can be used to explore a potential companion therapy using an engineered HMGB1 protein.
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OCT in Neurological Practice: Use of Retinal Layers to Help Diagnose and Follow Neurological Diseases
This study tests whether optical coherence tomography (OCT) of the retina can help in diagnosing and tracking multiple sclerosis, Alzheimer's, Parkinson's, migraines, and other headaches compared with healthy people.
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Blood tests using plasma biomarkers to diagnose and track Alzheimer’s disease
A large, year-long study in Milan is testing whether blood markers can help diagnose Alzheimer’s and predict how it will progress in people with memory concerns.
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Liver Cancer Registry at San Raffaele Hospital
This project tests whether a large registry can help identify biomarkers and patterns in patients with liver cancer and biliary tract cancer who come to San Raffaele Hospital.
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ATLG Levels During Autologous Stem Cell Transplant for MS
This observational study will test ATLG pharmacokinetics and immune recovery in adults with multiple sclerosis undergoing autologous HSCT.
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Genetic and blood markers linked to Menière's disease and symptoms
This project will test whether common gene variants and blood markers that control inner-ear ion balance differ between people with Menière's disease, people with vestibular migraine, and people without vestibular disorders.
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A registry for adults with esophageal movement and reflux problems.
This project will collect esophageal function tests (manometry, pH-impedance, FLIP) and clinical data from adults with reflux or swallowing symptoms to see if combining these results helps guide diagnosis and long-term care.
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Measuring How Gait Affects People with Gait Disorders Using Wearable Sensors
This study looks at how wearable sensors can measure gait in men and women with gait disorders and compares it to healthy volunteers to see if the sensors reliably capture movement patterns.
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Looking at blood markers linked to bone, muscle, and energy metabolism
This project will look at past blood tests from adults to see if specific bone turnover and formation markers relate to muscle function and energy metabolism.
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Stereotactic Body Radiotherapy with Continuous Tracking for Kidney Tumors
This trial tests a precise, high-dose SBRT approach to treat primary or secondary kidney tumors in adults using robotic tracking to see if it reduces kidney and treatment-related side effects.
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Mosunetuzumab for adults with relapsed/refractory follicular lymphoma after at least two prior therapies (compassionate use)
This project will see if the antibody drug mosunetuzumab helps adults with follicular lymphoma that has come back or stopped responding after at least two prior treatments when given through a compassionate use program.
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Digital platform for early detection of Alzheimer-related memory impairment
The platform will be tested to see if combining EEG, eye-tracking, and blood flow sensors can detect early memory-related cognitive impairment in people aged 55–80.
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Observational register of adults with diabetes and endocrine/metabolic disorders
This study will collect medical information from adults with diabetes or related metabolic and endocrine conditions to see how markers relate to disease severity and progression.
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Cost-helpful look at iliac branch endoprostheses in aorto-iliac aneurysm repairs
This observational study tests the cost-effectiveness of Iliac Branch Endoprostheses in adults who undergo open or endovascular repair for aorto-iliac aneurysm.
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Three-day discharge after distal pancreatectomy feasibility and effectiveness
This study tests whether selected patients can go home 3 days after a minimally invasive distal pancreatectomy and still do well.
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Plant-based, high-fiber diets and the gut microbiome in smoldering multiple myeloma
This 12-week program will try a high-fiber plant-based diet in people with smoldering multiple myeloma to see if it changes gut bacteria and raises short-chain fatty acids.
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Using patient-reported questionnaires to monitor quality of life during first-line chemo-immunotherapy for advanced NSCLC
This project will test whether regular online questionnaires about symptoms and quality of life can help track health and treatment effects in adults with stage IV NSCLC starting first-line chemo-immunotherapy.
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S100B blood changes in emergency patients with head trauma
This study will test whether a blood test for the protein S100B can reliably rule out brain injury in people who arrive at the ER within six hours of a head injury.
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5‑fraction whole‑breast radiation with a simultaneous boost versus standard 15‑fraction radiation for younger or unfavorable breast cancer
This will see if a very short 5‑session whole‑breast radiation with a boost to the tumor bed works as well as the standard 15‑session regimen for younger or higher‑risk breast cancer patients after breast‑conserving surgery.
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A mobile tool to help patients with urothelial carcinoma assess their quality of life
This study is testing a new mobile app to help patients with urothelial carcinoma track their quality of life and make better decisions about their treatment.
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Exploring the link between jaw disorders and sleep issues
This study is trying to see if people with jaw problems also have sleep issues and how these two conditions might be connected.
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Single‑session targeted partial breast radiation with a simultaneous boost for early-stage favorable‑subtype breast cancer
This trial will test whether a single high‑dose, targeted radiation session with a built‑in boost works as well as a five‑fraction schedule for women 40 and older with early, node‑negative luminal A or B HER2‑negative breast cancer after surgery.
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European venous disease registry for lower limbs
This project collects health and treatment information over ten years to see which treatments and outcomes occur in adults with new imaging-confirmed deep venous disease of the lower limbs, including the iliac, common femoral veins, or the inferior vena cava.
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Using MRI and tumor genetics to guide treatment for small kidney tumors
This project will test whether combining MRI images with tumor biopsy genetics and tissue mapping can help guide treatment choices for adults with small (≤4 cm) kidney tumors who are having surgery.
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Comparing non-invasive electrical stimulation plus rehabilitation to improve balance and walking in Parkinson's disease
This study will test whether adding different types of non-invasive electrical stimulation to gait and balance training helps people with Parkinson's disease who have postural instability and walking problems.
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Using cangrelor to improve outcomes in patients with cardiogenic shock on ECMO
This study is testing if adding a medication called cangrelor can help patients in cardiogenic shock on ECMO have better outcomes while reducing bleeding risks during their treatment.
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Predicting responses in metastatic lung cancer using AI
This study is testing an AI tool to see if it can help doctors predict how well patients with advanced lung cancer will respond to immunotherapy and chemo-immunotherapy treatments.
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Using advanced CT to find liver cancer spread from colorectal cancer
This study is testing a new type of CT scan to see if it can better find liver cancer spread in adults with colorectal cancer who haven't had a biopsy yet.
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Using multi-omics markers to find invasive IPMNs
This project tests whether combining genetic, metabolic, transcriptomic and environmental markers can help identify which adults with IPMNs have or will develop invasive pancreatic cancer.
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Understanding how people can wake up without alarms
This study looks at how some people can wake up on their own without alarms to see what helps them do that and what it means for their brain and sleep.
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Digital model for early diagnosis and monitoring of obstructive sleep apnea
This study is testing a new digital approach to help diagnose and monitor people with obstructive sleep apnea to see if it can improve their treatment and understanding of related cognitive issues.
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Evaluating the LIRA method for sizing in patients with bicuspid aortic valves
This study is testing a new sizing method for heart valve replacement in adults with a specific type of heart valve problem to see if it can make the procedure safer and more effective.
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Improving diagnosis of endometriosis and adenomyosis using advanced analysis techniques
This study is trying to find better ways to diagnose endometriosis and adenomyosis in women by using advanced techniques that look at genetics and imaging to help personalize treatments.
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Creating a biobank for studying bilio-pancreatic diseases
This study is creating a collection of biological samples and health information to see how genes and environment affect the risk of bilio-pancreatic diseases.
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Pre-surgery ultrahypofractionated stereotactic radiotherapy with targeted dose boost for glioblastoma
This trial will test whether a short course of focused pre-surgery stereotactic radiotherapy with an extra, imaging-guided dose boost helps people with operable glioblastoma.
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Evaluating advanced radiotherapy techniques for prostate cancer
This study is testing different advanced radiation treatments for prostate cancer to see how well they work and how they affect patients' lives.
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Ultra‑high‑resolution CT to look for lung and heart damage in progressive interstitial lung disease
This project will use advanced multidimensional CT scans to see if one noninvasive test can measure both lung fibrosis and early heart involvement in adults with progressive or long‑standing interstitial lung disease.
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Understanding how inflammation affects treatment response in acute myeloid leukemia
This study looks at how inflammation affects the response to treatment in newly diagnosed acute myeloid leukemia patients to see if it can help improve their care.
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Building a multiomic database using advanced imaging techniques
This study is trying to build a big database using advanced imaging techniques to see how different health information can help better understand and prevent diseases in adult patients.
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New imaging and molecular tests to detect bowel fibrosis in ulcerative colitis
We will test whether intestinal ultrasound with shear wave elastography plus molecular markers from biopsy can detect fibrosis in adults with ulcerative colitis.
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San Raffaele registry of adults receiving vitamin D treatment
This project will see how vitamin D supplements are used and affect adults with low vitamin D who attend the San Raffaele outpatient clinic.
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Observing recovery patterns in stroke survivors
This study looks at how different factors right after a stroke affect how well survivors recover over time.
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AI detection of vertebral fractures on routine chest‑abdomen CT for men over 50
This project will try AI software to find vertebral fractures on chest‑abdomen CT scans in men aged 50 and older who have CTs for reasons other than bone disease.
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San Raffaele registry for adults with eosinophilic esophagitis
This registry will collect clinical, endoscopic, and biopsy information from adults with eosinophilic esophagitis who are referred to the San Raffaele Motility and EoE Unit.
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Registry of genetic, molecular, and diversity differences in women with acute coronary syndrome
This project will collect clinical, genetic, biochemical, and molecular information from women with acute coronary syndrome across Italy to see if differences by age, ethnicity, or disease type relate to presentation and outcomes.
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Registry and biobank for infectious diseases
This study is creating a database and collection of samples from patients with different infectious diseases to see how these illnesses affect treatment outcomes and to learn more about managing them.
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Observing quality of life in prostate cancer patients after biopsy and surgery
This study looks at how the quality of life changes for men with prostate cancer after they have a biopsy or surgery, by collecting their experiences through questionnaires over many years.
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Understanding the quality of life and outcomes for testicular cancer patients
This study is trying to understand how testicular cancer affects patients' quality of life and well-being over time to help improve their care and treatment.
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Combining radioembolization and biological therapy for advanced bile duct cancer
This study is testing a new treatment for advanced bile duct cancer that combines a special type of radiation therapy with immune and chemotherapy drugs to see if it can work better for patients whose tumors can't be removed.
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Examining factors affecting treatment response in gastroenteropancreatic neuroendocrine tumors
This study looks at how different factors related to tumors and patients affect how well treatments work for people with gastroenteropancreatic neuroendocrine tumors.
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Registry of images and videos from endoscopic procedures for pancreatic diseases
This study is collecting images and videos from endoscopic procedures on patients with pancreatic diseases to help improve how these conditions are understood and treated.
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New treatments for muscle-invasive bladder cancer
This study is testing new treatments for muscle-invasive bladder cancer in patients who can't take standard chemotherapy to see if a combination of two drugs can help improve their outcomes.
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How frailty and chronic conditions influence each other and change over time
This project will re-examine adults with frailty, muscle loss, or mild cognitive problems to try to see if frailty predicts how chronic diseases progress and which blood or imaging markers change.
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Understanding the causes of sarcopenic obesity in older adults
This study looks at how obesity and loss of muscle in older adults are connected and what causes this problem, focusing on people who are having hip surgery and healthy seniors.
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Advanced radiotherapy for gynecological cancer patients
This study looks at how advanced types of radiotherapy affect women with gynecological cancer to see how well they work and what side effects they might cause.
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Using advanced imaging to diagnose significant prostate cancer
This study is testing a new imaging method that combines PET and MRI scans to see if it can better diagnose significant prostate cancer and reduce the need for unnecessary biopsies in patients at low risk.
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Evaluating mechanical thrombectomy for deep vein thrombosis
This study is testing if a procedure called mechanical thrombectomy can safely help people with serious blood clots in their legs feel better.
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Investigating the effects of therapies on multiple sclerosis progression after bone marrow transplantation
This study is testing whether certain therapies can help people with relapsing-remitting multiple sclerosis avoid worsening their condition after undergoing a specific type of stem cell transplant.
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Improving safety and accuracy of brain biopsies for lymphoma patients
This study is testing if looking at MRI images can help doctors safely and accurately diagnose brain lymphoma in patients who might not be able to have regular biopsies.
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Study of aortic arch anatomical variations
This study looks at the different shapes of the aortic arch in people with and without aneurysms to see how a common variation might relate to heart problems.
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Evaluating cognitive impairment in patients with focal cryptogenic epilepsy
This study is testing how epilepsy affects thinking skills in people with different types of epilepsy to see if brain activity patterns can help understand their cognitive challenges better.
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Improving treatment for post-thrombotic syndrome using ultrasound techniques
This study is testing if using ultrasound to help clear blocked veins can relieve symptoms for people with post-thrombotic syndrome after a deep vein thrombosis.
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Analyzing genetic mutations in kidney cells of patients with Von Hippel-Lindau disease
This study looks at whether kidney cells from people with Von Hippel-Lindau disease have more genetic changes compared to those without the condition.
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Observational study on the quality of life of outpatients with urologic diseases
This study looks at how urologic diseases affect the quality of life for outpatients to see how their treatment and overall health can be improved.
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Collection of biological samples from patients and healthy donors for urological diseases
This study is collecting blood, urine, and other samples from patients with urological diseases and healthy donors to see if they can find new ways to diagnose and understand these conditions better.
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Observing the quality of life in patients with benign prostatic hyperplasia
This study looks at how different treatments for benign prostatic hyperplasia affect the daily lives and well-being of patients.
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Observing quality of life in patients after bladder cancer surgery
This study looks at how bladder cancer surgery affects the quality of life for patients over about 10 years by checking in with them each year.
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Observing cancer relapse and quality of life after kidney surgery
This study looks at how kidney surgery affects cancer relapse and the overall quality of life for patients with a specific type of urinary tract cancer.
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Evaluating the role of 18F-PSMA PET imaging in prostate cancer
This study is testing how well 18F-PSMA PET imaging can help doctors understand and predict the progression of prostate cancer in patients at different stages of the disease.
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Tracking quality of life and relapses in bladder cancer patients after surgery
This study is tracking how bladder cancer patients feel and whether their cancer comes back after surgery over the next 10 years.
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Observing kidney stone patients undergoing endoscopic surgery
This study looks at kidney stone patients who are having a special type of surgery to see how their genes and stone types affect their treatment and recovery.
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Using 68Ga-DOTATOC PET to evaluate gastroenteropancreatic neuroendocrine tumors
This study is testing if a special type of PET scan can help doctors better diagnose gastroenteropancreatic neuroendocrine tumors in adults.
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Observing the effects of kidney cancer surgery on patients
This study looks at how kidney cancer surgery affects patients over time to see how it impacts their quality of life and chances of relapse.
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Creating personalized 3D models of pancreatic neuroendocrine tumors
This study is trying to create personalized 3D models of pancreatic neuroendocrine tumors from patients' surgical samples to better understand the disease and test new treatments.
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Analyzing blood samples for bladder cancer biomarkers
This study is testing whether analyzing blood samples can help find important markers for bladder cancer in patients with early-stage disease to improve their treatment and quality of life.
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Comparing treatments for malignant gastric outlet obstruction caused by pancreatic cancer
This study is testing which of three different treatments works best for people with stomach blockages caused by pancreatic cancer to see how they feel and eat afterwards.
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Using CT to assess heart tissue health
This study is testing if advanced heart scans can help doctors see heart tissue damage and changes in patients with different heart problems who need a CT scan.
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High-dose single fraction radiation therapy for prostate cancer
This study is testing a high-dose radiation treatment for localized prostate cancer to see if it is safe and effective while protecting the urethra.
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Investigating the glymphatic system's role in migraine
This study is trying to see how the brain's cleaning system might affect migraine attacks by looking at brain scans and sleep patterns in people with migraines and healthy individuals.
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Characterizing immune cells in malignant brain tumors
This study is trying to understand how immune cells behave in people with malignant brain tumors by looking at their blood and tumor samples before and after surgery.
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Evaluating Fertility Treatments in Women with Rheumatic Diseases
This study is trying to see how well fertility treatments work for women with rheumatic diseases and if these treatments affect their health conditions.
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Evaluating placental markers in pregnant women with and without antiphospholipid syndrome
This study is trying to see if certain markers in the blood can help predict the risk of preeclampsia in pregnant women with antiphospholipid syndrome compared to those without it.
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Characterizing patients treated at internal medicine clinics
This study looks at patients with serious health issues treated in internal medicine clinics to see how their different conditions affect their care and to find better ways to diagnose and treat them.
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Investigating the role of glutamate in glioblastoma
This study is testing how levels of glutamate in blood and spinal fluid might affect the growth of glioblastoma in patients suspected of having this aggressive brain tumor.
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Probiotic treatment for children with new onset Type 1 Diabetes
This study is testing if a special probiotic can help children who have just been diagnosed with Type 1 Diabetes by improving their gut health and preserving their insulin production over a year.
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Investigating PuraBond for controlling bleeding during abdominal aorta surgery
This study is testing if the PuraBond hemostatic agent can help control bleeding during abdominal aorta surgery for patients who struggle with standard methods.
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National Parkinson's biobank with whole genome sequencing and patient-derived stem-cell testing
This project will test whether combining whole genome sequencing and patient-derived stem cells can help find rare genetic changes linked to Parkinson's disease and REM sleep behavior disorder.
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Evaluating liver embolization techniques for tumor management
This study tests different liver embolization methods to see how well they help people with liver tumors live longer and maintain liver function while they continue their usual treatments.
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Registry collecting radiological data on pancreatic cancer
This study is collecting medical imaging data from patients with pancreatic cancer to see how their condition progresses and how well they respond to treatment.
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Home-based virtual reality treatment for arm rehabilitation in multiple sclerosis
This study tests if using virtual reality at home can help people with multiple sclerosis improve their arm movement and function.
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Comparing two radiation therapies for treating bone metastases in cancer patients
This study is testing two different types of radiation therapy for cancer patients with bone metastases to see which one works better in treating their condition.
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Observational study of HIV-positive individuals receiving long-acting antiretroviral therapy
This study is looking at how well long-acting HIV medications work for people living with HIV and how they affect their overall health and quality of life over 48 weeks.
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Evaluating pancreatic cancer changes during treatment
This study is testing how pancreatic cancer changes during treatment in patients who have early-stage disease by comparing samples taken before and after chemotherapy.
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Analyzing the immune response in relapsed Acute Myeloid Leukemia after stem cell transplant
This study is trying to understand how the immune system reacts when Acute Myeloid Leukemia comes back after a stem cell transplant, to help create better treatment plans for patients.
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Registry for Transoral Incisionless Fundoplication for GERD
This study tracks how well a new procedure called transoral incisionless fundoplication works for people with GERD by looking at their symptoms and quality of life over five years.
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CSF DNA testing to improve diagnosis and monitoring in primary CNS lymphoma
This project will test whether sequencing DNA from spinal fluid can help diagnose and monitor people with suspected or confirmed primary CNS lymphoma.
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Registry for patients with poor grade aneurysmal subarachnoid hemorrhage
This study is trying to understand how to better treat and predict outcomes for patients with severe brain bleeding caused by aneurysms, looking at both immediate and long-term effects.
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Fixed-duration treatment for chronic lymphocytic leukemia with ibrutinib and obinutuzumab
This study is testing a new treatment plan using ibrutinib and obinutuzumab for people with chronic lymphocytic leukemia who haven't been treated before, to see if it can help them reach a point where the disease is undetectable in their bone marrow.
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Registry analyzing outcomes of therapeutic endoscopic ultrasound procedures
This study looks at how well therapeutic endoscopic ultrasound works for people with gastrointestinal issues and what factors might affect the results.
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Combining Venetoclax, Rituximab, and Ibrutinib for Treating Chronic Lymphocytic Leukemia
This study is testing if adding ibrutinib to a year-long treatment of venetoclax and rituximab can help people with newly diagnosed Chronic Lymphocytic Leukemia reach a state where the disease is undetectable.
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Innovative therapies for liver metastases in cancer patients
This study is testing new ways to understand and treat liver tumors in patients with advanced colorectal and pancreatic cancer to see if it can lead to better therapies.
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Registry of HIV-1 Patients with Drug Resistance
This study is tracking people with HIV-1 who have drug resistance to see how different treatments work for them over time.
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Virtual reality rehab for people with neck pain
We will test whether adding virtual-reality guided sensorimotor exercises to standard therapy helps adults (18–70) with chronic neck pain or whiplash improve pain and movement after six weeks.
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Microwave ablation for treating small kidney and liver tumors
This study is testing whether microwave ablation can safely and effectively treat small kidney and liver tumors in patients while they continue their regular care.
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Monitoring small kidney tumors without immediate treatment
This study is testing whether closely monitoring small kidney tumors in people over 50 can be a safe alternative to immediate surgery.
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Ibuprofen with G‑CSF and Plerixafor to mobilize stem cells for people with X‑CGD
This trial will test whether adding ibuprofen to G‑CSF and plerixafor helps collect enough stem cells for adults with X‑linked chronic granulomatous disease.
Quick answers
How many clinical trials run by IRCCS San Raffaele are recruiting right now?
110, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 11 countries. The most sites are in Italy (110 trials), France (2 trials), Turkey (Türkiye) (2 trials), Portugal (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 6. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.