Using CT to assess heart tissue health
CT-based Myocardial Characterization
IRCCS San Raffaele · NCT06029400
This study is testing if advanced heart scans can help doctors see heart tissue damage and changes in patients with different heart problems who need a CT scan.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2200 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | IRCCS San Raffaele (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Milan) |
| Trial ID | NCT06029400 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify myocardial fibrosis and assess myocardial scar and extracellular matrix remodeling using advanced cardiac CT techniques. It focuses on patients with various cardiovascular conditions who require a cardiac CT for clinical indications such as stable angina, heart failure, or arrhythmias. The study seeks to provide a non-invasive alternative to cardiac magnetic resonance imaging, which has limitations in certain patient populations and acute settings.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with specific cardiovascular conditions requiring cardiac CT.
Not a fit: Patients under 18, pregnant or breastfeeding women, and those with contraindications to iodinated contrast agents may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the diagnosis and management of cardiovascular diseases by providing a reliable non-invasive imaging option.
How similar studies have performed: While cardiac CT is a well-established imaging modality, this specific approach to myocardial characterization is relatively novel and may offer new insights into cardiovascular disease management.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age ≥ 18 years; * no contraindication to cCT * signed informed consent * clinical indication to cCT for the following reason: stable angina, heart failure, atrial/ ventricular arrhythmias, acute chest pain with need of "triple-rule-out" scan, planning of valvular repair/substitution, structural and infiltrative cardiomyopathy, new onset ECG alteration, troponin increase. Exclusion Criteria: * age \< 18 years * pregnancy and/or breastfeeding * contraindications to iodinated contrast agent administration or impaired renal function (eGFR ≤ 30 mL/min); * inability to sustain a brief breath hold (5 seconds)
Where this trial is running
Milan
- IRCCS San Raffaele — Milan, Italy (RECRUITING)
Study contacts
- Study coordinator: Antonio Esposito
- Email: esposito.antonio@hsr.it
- Phone: 02 2643 6102
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cardiovascular Diseases